Journal Article (Review Article)

DKFZ-2018-01391

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Acute and chronic effects of exercise on the kynurenine pathway in humans - A brief review and future perspectives.

Metcalfe, A. J. ; Koliamitra, C. ; Javelle, F. ; Bloch, W. ; Zimmer, P. (Last author)DKFZ*

2018
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.physbeh.2018.07.015

Abstract: Tryptophan (TRP) is an essential amino acid. Metabolites of TRP have been identified as important mediators in immune regulation and function of the central nervous system. Inflammation strongly stimulates to the breakdown of TRP into Kynurenine (KYN), representing the initial step of the KYN pathway. Recently, exercise interventions have been able to demonstrate a modification of the KYN pathway plausibly by altering inflammation. However, modifications differ between acute and chronic exercise interventions. As such, this review examines the current studies that have investigated the effect of an acute (single bout) or chronic (training) exercise intervention on levels of TRP and KYN in both healthy and diseased populations.

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Contributing Institute(s):

1. Bewegung, Präventionsforschung und Krebs (G210)

Research Program(s):

1. 317 - Translational cancer research (POF3-317) (POF3-317)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Social Sciences Citation Index ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record

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