TY  - JOUR
AU  - Metcalfe, Alan J
AU  - Koliamitra, Christina
AU  - Javelle, Florian
AU  - Bloch, Wilhelm
AU  - Zimmer, Philipp
TI  - Acute and chronic effects of exercise on the kynurenine pathway in humans - A brief review and future perspectives.
JO  - Physiology & behavior
VL  - 194
SN  - 0031-9384
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2018-01391
SP  - 583 - 587
PY  - 2018
AB  - Tryptophan (TRP) is an essential amino acid. Metabolites of TRP have been identified as important mediators in immune regulation and function of the central nervous system. Inflammation strongly stimulates to the breakdown of TRP into Kynurenine (KYN), representing the initial step of the KYN pathway. Recently, exercise interventions have been able to demonstrate a modification of the KYN pathway plausibly by altering inflammation. However, modifications differ between acute and chronic exercise interventions. As such, this review examines the current studies that have investigated the effect of an acute (single bout) or chronic (training) exercise intervention on levels of TRP and KYN in both healthy and diseased populations.
LB  - PUB:(DE-HGF)16
C6  - pmid:30031753
DO  - DOI:10.1016/j.physbeh.2018.07.015
UR  - https://inrepo02.dkfz.de/record/136962
ER  -