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@ARTICLE{Metcalfe:136962,
      author       = {A. J. Metcalfe and C. Koliamitra and F. Javelle and W.
                      Bloch and P. Zimmer$^*$},
      title        = {{A}cute and chronic effects of exercise on the kynurenine
                      pathway in humans - {A} brief review and future
                      perspectives.},
      journal      = {Physiology $\&$ behavior},
      volume       = {194},
      issn         = {0031-9384},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2018-01391},
      pages        = {583 - 587},
      year         = {2018},
      abstract     = {Tryptophan (TRP) is an essential amino acid. Metabolites of
                      TRP have been identified as important mediators in immune
                      regulation and function of the central nervous system.
                      Inflammation strongly stimulates to the breakdown of TRP
                      into Kynurenine (KYN), representing the initial step of the
                      KYN pathway. Recently, exercise interventions have been able
                      to demonstrate a modification of the KYN pathway plausibly
                      by altering inflammation. However, modifications differ
                      between acute and chronic exercise interventions. As such,
                      this review examines the current studies that have
                      investigated the effect of an acute (single bout) or chronic
                      (training) exercise intervention on levels of TRP and KYN in
                      both healthy and diseased populations.},
      subtyp        = {Review Article},
      cin          = {G210},
      ddc          = {570},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30031753},
      doi          = {10.1016/j.physbeh.2018.07.015},
      url          = {https://inrepo02.dkfz.de/record/136962},
}