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@ARTICLE{Singhal:137567,
      author       = {M. Singhal$^*$ and X. Liu and D. Inverso$^*$ and K. Jiang
                      and J. Dai and H. He and S. Bartels$^*$ and W. Li and A. A.
                      Abdul Pari$^*$ and N. Gengenbacher$^*$ and E.
                      Besemfelder$^*$ and L. Hui and H. Augustin$^*$ and J. Hu},
      title        = {{E}ndothelial cell fitness dictates the source of
                      regenerating liver vasculature.},
      journal      = {Journal of experimental medicine},
      volume       = {215},
      number       = {10},
      issn         = {1540-9538},
      address      = {New York, NY},
      publisher    = {Rockefeller Univ. Press},
      reportid     = {DKFZ-2018-01447},
      pages        = {2497-2508},
      year         = {2018},
      note         = {DKFZ-ZMBH Allianz},
      abstract     = {Neoangiogenesis plays a key role in diverse
                      pathophysiological conditions, including liver regeneration.
                      Yet, the source of new endothelial cells (ECs) remains
                      elusive. By analyzing the regeneration of the liver
                      vasculature in irradiation-based myeloablative and
                      nonmyeloablative bone marrow transplantation mouse models,
                      we discovered that neoangiogenesis in livers with intact
                      endothelium was solely mediated by proliferation of resident
                      ECs. However, following irradiation-induced EC damage, bone
                      marrow-derived mononuclear cells were recruited and
                      incorporated into the vasculature. Further experiments with
                      direct bone marrow infusion or granulocyte
                      colony-stimulating factor (G-CSF)-mediated progenitor cell
                      mobilization, which resembles clinically relevant stem cell
                      therapy, demonstrated that bone marrow-derived cells did not
                      contribute to the regeneration of liver vasculature after
                      two-thirds partial hepatectomy (PHx). Taken together, the
                      data reconcile many of the discrepancies in the literature
                      and highlight that the cellular source of regenerating
                      endothelium depends on the fitness of the residual
                      vasculature.},
      cin          = {A190 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)A190-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30194265},
      doi          = {10.1084/jem.20180008},
      url          = {https://inrepo02.dkfz.de/record/137567},
}