Journal Article

DKFZ-2018-01447

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Endothelial cell fitness dictates the source of regenerating liver vasculature.

Singhal, M. (First author)DKFZ* ; Liu, X. ; Inverso, D.DKFZ* ; Jiang, K. ; Dai, J. ; He, H. ; Bartels, S.DKFZ* ; Li, W. ; Abdul Pari, A. A.DKFZ* ; Gengenbacher, N.DKFZ* ; Besemfelder, E.DKFZ* ; Hui, L. ; Augustin, H. (Last author)DKFZ* ; Hu, J.

2018
Rockefeller Univ. Press New York, NY

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Please use a persistent id in citations: doi:10.1084/jem.20180008

Abstract: Neoangiogenesis plays a key role in diverse pathophysiological conditions, including liver regeneration. Yet, the source of new endothelial cells (ECs) remains elusive. By analyzing the regeneration of the liver vasculature in irradiation-based myeloablative and nonmyeloablative bone marrow transplantation mouse models, we discovered that neoangiogenesis in livers with intact endothelium was solely mediated by proliferation of resident ECs. However, following irradiation-induced EC damage, bone marrow-derived mononuclear cells were recruited and incorporated into the vasculature. Further experiments with direct bone marrow infusion or granulocyte colony-stimulating factor (G-CSF)-mediated progenitor cell mobilization, which resembles clinically relevant stem cell therapy, demonstrated that bone marrow-derived cells did not contribute to the regeneration of liver vasculature after two-thirds partial hepatectomy (PHx). Taken together, the data reconcile many of the discrepancies in the literature and highlight that the cellular source of regenerating endothelium depends on the fitness of the residual vasculature.

Note: DKFZ-ZMBH Allianz

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Contributing Institute(s):

1. A190 Vaskuläre Onkologie und Metastasierung (A190)
2. DKTK Heidelberg (L101)

Research Program(s):

1. 311 - Signalling pathways, cell and tumor biology (POF3-311) (POF3-311)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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