guest ::
| Home > Publications database > Endothelial cell fitness dictates the source of regenerating liver vasculature. > print |
| Home > Publications database > Endothelial cell fitness dictates the source of regenerating liver vasculature. > print |
| 001 | 137567 | ||
| 005 | 20240229105110.0 | ||
| 024 | 7 | _ | |a 10.1084/jem.20180008 |2 doi |
| 024 | 7 | _ | |a pmid:30194265 |2 pmid |
| 024 | 7 | _ | |a 0022-1007 |2 ISSN |
| 024 | 7 | _ | |a 1540-9538 |2 ISSN |
| 024 | 7 | _ | |a altmetric:47965234 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2018-01447 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Singhal, Mahak |0 P:(DE-He78)1956b17ee4a34a5fdd72287aca7cdc0a |b 0 |e First author |
| 245 | _ | _ | |a Endothelial cell fitness dictates the source of regenerating liver vasculature. |
| 260 | _ | _ | |a New York, NY |c 2018 |b Rockefeller Univ. Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1660198382_9214 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a DKFZ-ZMBH Allianz |
| 520 | _ | _ | |a Neoangiogenesis plays a key role in diverse pathophysiological conditions, including liver regeneration. Yet, the source of new endothelial cells (ECs) remains elusive. By analyzing the regeneration of the liver vasculature in irradiation-based myeloablative and nonmyeloablative bone marrow transplantation mouse models, we discovered that neoangiogenesis in livers with intact endothelium was solely mediated by proliferation of resident ECs. However, following irradiation-induced EC damage, bone marrow-derived mononuclear cells were recruited and incorporated into the vasculature. Further experiments with direct bone marrow infusion or granulocyte colony-stimulating factor (G-CSF)-mediated progenitor cell mobilization, which resembles clinically relevant stem cell therapy, demonstrated that bone marrow-derived cells did not contribute to the regeneration of liver vasculature after two-thirds partial hepatectomy (PHx). Taken together, the data reconcile many of the discrepancies in the literature and highlight that the cellular source of regenerating endothelium depends on the fitness of the residual vasculature. |
| 536 | _ | _ | |a 311 - Signalling pathways, cell and tumor biology (POF3-311) |0 G:(DE-HGF)POF3-311 |c POF3-311 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Liu, Xiaoting |b 1 |
| 700 | 1 | _ | |a Inverso, Donato |0 P:(DE-He78)a2d0ba20ff9bcfeccbdab04513fbf8f0 |b 2 |
| 700 | 1 | _ | |a Jiang, Kai |b 3 |
| 700 | 1 | _ | |a Dai, Jianing |b 4 |
| 700 | 1 | _ | |a He, Hao |b 5 |
| 700 | 1 | _ | |a Bartels, Susanne |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Li, Weiping |b 7 |
| 700 | 1 | _ | |a Abdul Pari, Ashik Ahmed |0 P:(DE-He78)81cd72bf4d0bacc59dc1d2b3b5c27be7 |b 8 |
| 700 | 1 | _ | |a Gengenbacher, Nicolas |0 P:(DE-He78)d2851af71b2aced0c34d8c71329c3bc5 |b 9 |
| 700 | 1 | _ | |a Besemfelder, Eva |0 P:(DE-He78)9be9200416a88a73cc9c25339b19b58f |b 10 |
| 700 | 1 | _ | |a Hui, Lijian |b 11 |
| 700 | 1 | _ | |a Augustin, Hellmut |0 P:(DE-He78)2e92d0ae281932fc7347d819fec36b0b |b 12 |e Last author |
| 700 | 1 | _ | |a Hu, Junhao |0 0000-0003-0699-1119 |b 13 |
| 773 | _ | _ | |a 10.1084/jem.20180008 |g p. jem.20180008 - |0 PERI:(DE-600)1477240-1 |n 10 |p 2497-2508 |t Journal of experimental medicine |v 215 |y 2018 |x 1540-9538 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:137567 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 0 |6 P:(DE-He78)1956b17ee4a34a5fdd72287aca7cdc0a |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)a2d0ba20ff9bcfeccbdab04513fbf8f0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 6 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 8 |6 P:(DE-He78)81cd72bf4d0bacc59dc1d2b3b5c27be7 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 9 |6 P:(DE-He78)d2851af71b2aced0c34d8c71329c3bc5 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 10 |6 P:(DE-He78)9be9200416a88a73cc9c25339b19b58f |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 12 |6 P:(DE-He78)2e92d0ae281932fc7347d819fec36b0b |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-311 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Signalling pathways, cell and tumor biology |x 0 |
| 914 | 1 | _ | |y 2018 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b J EXP MED : 2015 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b J EXP MED : 2015 |
| 920 | 1 | _ | |0 I:(DE-He78)A190-20160331 |k A190 |l A190 Vaskuläre Onkologie und Metastasierung |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)L101-20160331 |k L101 |l DKTK Heidelberg |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)A190-20160331 |
| 980 | _ | _ | |a I:(DE-He78)L101-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|