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000137569 1001_ $$00000-0003-3345-7333$$aBradbury, Kathryn E$$b0
000137569 245__ $$aCirculating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition.
000137569 260__ $$aBognor Regis$$bWiley-Liss$$c2019
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000137569 520__ $$aInsulin-like growth factor (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case-control study of 1221 melanoma cases and 1221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity, and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth=0.93 (95% confidence interval (CI): 0.71 to 1.22)). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by sex, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma. This article is protected by copyright. All rights reserved.
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000137569 7001_ $$aAppleby, Paul N$$b1
000137569 7001_ $$aTipper, Sarah J$$b2
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000137569 7001_ $$00000-0002-4557-3772$$aKvaskoff, Marina$$b5
000137569 7001_ $$aOvervad, Kim$$b6
000137569 7001_ $$aTjønneland, Anne$$b7
000137569 7001_ $$aHalkjaer, Jytte$$b8
000137569 7001_ $$aCevenka, Iris$$b9
000137569 7001_ $$aMahamat-Saleh, Yahya$$b10
000137569 7001_ $$aBonnet, Fabrice$$b11
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000137569 7001_ $$aBoeing, Heiner$$b14
000137569 7001_ $$aTrichopoulou, Antonia$$b15
000137569 7001_ $$00000-0003-1441-897X$$aLa Vecchia, Carlo$$b16
000137569 7001_ $$aStratigos, Alexander J$$b17
000137569 7001_ $$00000-0002-5558-2437$$aPalli, Domenico$$b18
000137569 7001_ $$aGrioni, Sara$$b19
000137569 7001_ $$00000-0003-0674-7757$$aMatullo, Giuseppe$$b20
000137569 7001_ $$aPanico, Salvatore$$b21
000137569 7001_ $$aTumino, Rosario$$b22
000137569 7001_ $$aPeeters, Petra H$$b23
000137569 7001_ $$aBueno-de-Mesquita, Bas$$b24
000137569 7001_ $$aGhiasvand, Reza$$b25
000137569 7001_ $$00000-0002-2083-2758$$aVeierød, Marit B$$b26
000137569 7001_ $$aWeiderpass, Elisabete$$b27
000137569 7001_ $$aBonet, Catalina$$b28
000137569 7001_ $$aMolina, Elena$$b29
000137569 7001_ $$aHuerta, José María$$b30
000137569 7001_ $$aLarrañaga, Nerea$$b31
000137569 7001_ $$aBarricarte, Aurelio$$b32
000137569 7001_ $$aMerino, Susana$$b33
000137569 7001_ $$aIsaksson, Karolin$$b34
000137569 7001_ $$aStocks, Tanja$$b35
000137569 7001_ $$00000-0002-5046-1820$$aLjuslinder, Ingrid$$b36
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000137569 7001_ $$00000-0002-6846-1204$$aRinaldi, Sabina$$b41
000137569 7001_ $$aTsilidis, Konstantinos K$$b42
000137569 7001_ $$aAune, Dagfinn$$b43
000137569 7001_ $$aRiboli, Elio$$b44
000137569 7001_ $$aKey, Timothy J$$b45
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