Journal Article

DKFZ-2018-01449

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Circulating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition.

Bradbury, K. E. ; Appleby, P. N. ; Tipper, S. J. ; Travis, R. C. ; Allen, N. E. ; Kvaskoff, M. ; Overvad, K. ; Tjønneland, A. ; Halkjaer, J. ; Cevenka, I. ; Mahamat-Saleh, Y. ; Bonnet, F. ; Kaaks, R.DKFZ* ; Turzanski Fortner, R.DKFZ* ; Boeing, H. ; Trichopoulou, A. ; La Vecchia, C. ; Stratigos, A. J. ; Palli, D. ; Grioni, S. ; Matullo, G. ; Panico, S. ; Tumino, R. ; Peeters, P. H. ; Bueno-de-Mesquita, B. ; Ghiasvand, R. ; Veierød, M. B. ; Weiderpass, E. ; Bonet, C. ; Molina, E. ; Huerta, J. M. ; Larrañaga, N. ; Barricarte, A. ; Merino, S. ; Isaksson, K. ; Stocks, T. ; Ljuslinder, I. ; Hemmingsson, O. ; Wareham, N. ; Khaw, K.-T. ; Gunter, M. J. ; Rinaldi, S. ; Tsilidis, K. K. ; Aune, D. ; Riboli, E. ; Key, T. J.

2019
Wiley-Liss Bognor Regis

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/ijc.31854

Abstract: Insulin-like growth factor (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case-control study of 1221 melanoma cases and 1221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity, and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth=0.93 (95% confidence interval (CI): 0.71 to 1.22)). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by sex, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma. This article is protected by copyright. All rights reserved.

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Contributing Institute(s):

1. Epidemiologie von Krebserkrankungen (C020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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