TY  - JOUR
AU  - Bradbury, Kathryn E
AU  - Appleby, Paul N
AU  - Tipper, Sarah J
AU  - Travis, Ruth C
AU  - Allen, Naomi E
AU  - Kvaskoff, Marina
AU  - Overvad, Kim
AU  - Tjønneland, Anne
AU  - Halkjaer, Jytte
AU  - Cevenka, Iris
AU  - Mahamat-Saleh, Yahya
AU  - Bonnet, Fabrice
AU  - Kaaks, Rudolf
AU  - Turzanski Fortner, Renée
AU  - Boeing, Heiner
AU  - Trichopoulou, Antonia
AU  - La Vecchia, Carlo
AU  - Stratigos, Alexander J
AU  - Palli, Domenico
AU  - Grioni, Sara
AU  - Matullo, Giuseppe
AU  - Panico, Salvatore
AU  - Tumino, Rosario
AU  - Peeters, Petra H
AU  - Bueno-de-Mesquita, Bas
AU  - Ghiasvand, Reza
AU  - Veierød, Marit B
AU  - Weiderpass, Elisabete
AU  - Bonet, Catalina
AU  - Molina, Elena
AU  - Huerta, José María
AU  - Larrañaga, Nerea
AU  - Barricarte, Aurelio
AU  - Merino, Susana
AU  - Isaksson, Karolin
AU  - Stocks, Tanja
AU  - Ljuslinder, Ingrid
AU  - Hemmingsson, Oskar
AU  - Wareham, Nick
AU  - Khaw, Kay-Tee
AU  - Gunter, Marc J
AU  - Rinaldi, Sabina
AU  - Tsilidis, Konstantinos K
AU  - Aune, Dagfinn
AU  - Riboli, Elio
AU  - Key, Timothy J
TI  - Circulating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition.
JO  - International journal of cancer
VL  - 144
IS  - 5
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2018-01449
SP  - 957-966
PY  - 2019
AB  - Insulin-like growth factor (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case-control study of 1221 melanoma cases and 1221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity, and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth=0.93 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:30191956
DO  - DOI:10.1002/ijc.31854
UR  - https://inrepo02.dkfz.de/record/137569
ER  -