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@ARTICLE{Bradbury:137569,
      author       = {K. E. Bradbury and P. N. Appleby and S. J. Tipper and R. C.
                      Travis and N. E. Allen and M. Kvaskoff and K. Overvad and A.
                      Tjønneland and J. Halkjaer and I. Cevenka and Y.
                      Mahamat-Saleh and F. Bonnet and R. Kaaks$^*$ and R.
                      Turzanski Fortner$^*$ and H. Boeing and A. Trichopoulou and
                      C. La Vecchia and A. J. Stratigos and D. Palli and S. Grioni
                      and G. Matullo and S. Panico and R. Tumino and P. H. Peeters
                      and B. Bueno-de-Mesquita and R. Ghiasvand and M. B. Veierød
                      and E. Weiderpass and C. Bonet and E. Molina and J. M.
                      Huerta and N. Larrañaga and A. Barricarte and S. Merino and
                      K. Isaksson and T. Stocks and I. Ljuslinder and O.
                      Hemmingsson and N. Wareham and K.-T. Khaw and M. J. Gunter
                      and S. Rinaldi and K. K. Tsilidis and D. Aune and E. Riboli
                      and T. J. Key},
      title        = {{C}irculating insulin-like growth factor {I} in relation to
                      melanoma risk in the {E}uropean {P}rospective
                      {I}nvestigation into {C}ancer and {N}utrition.},
      journal      = {International journal of cancer},
      volume       = {144},
      number       = {5},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-01449},
      pages        = {957-966},
      year         = {2019},
      abstract     = {Insulin-like growth factor (IGF-I) regulates cell
                      proliferation and apoptosis, and is thought to play a role
                      in tumour development. Previous prospective studies have
                      shown that higher circulating concentrations of IGF-I are
                      associated with a higher risk of cancers at specific sites,
                      including breast and prostate. No prospective study has
                      examined the association between circulating IGF-I
                      concentrations and melanoma risk. A nested case-control
                      study of 1221 melanoma cases and 1221 controls was performed
                      in the European Prospective Investigation into Cancer and
                      Nutrition cohort, a prospective cohort of 520,000
                      participants recruited from 10 European countries.
                      Conditional logistic regression was used to estimate odds
                      ratios (ORs) for incident melanoma in relation to
                      circulating IGF-I concentrations, measured by immunoassay.
                      Analyses were conditioned on the matching factors and
                      further adjusted for age at blood collection, education,
                      height, BMI, smoking status, alcohol intake, marital status,
                      physical activity, and in women only, use of menopausal
                      hormone therapy. There was no significant association
                      between circulating IGF-I concentration and melanoma risk
                      (OR for highest vs lowest fifth=0.93 $(95\%$ confidence
                      interval (CI): 0.71 to 1.22)). There was no significant
                      heterogeneity in the association between IGF-I
                      concentrations and melanoma risk when subdivided by sex, age
                      at blood collection, BMI, height, age at diagnosis, time
                      between blood collection and diagnosis, or by anatomical
                      site or histological subtype of the tumour
                      (Pheterogeneity≥0.078). We found no evidence for an
                      association between circulating concentrations of IGF-I
                      measured in adulthood and the risk of melanoma. This article
                      is protected by copyright. All rights reserved.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30191956},
      doi          = {10.1002/ijc.31854},
      url          = {https://inrepo02.dkfz.de/record/137569},
}