TY  - JOUR
AU  - Kather, Jakob Nikolas
AU  - Suarez-Carmona, Meggy
AU  - Charoentong, Pornpimol
AU  - Weis, Cleo-Aron
AU  - Hirsch, Daniela
AU  - Bankhead, Peter
AU  - Horning, Marcel
AU  - Ferber, Dyke
AU  - Kel, Ivan
AU  - Herpel, Esther
AU  - Schott, Sarah
AU  - Zörnig, Inka
AU  - Utikal, Jochen
AU  - Marx, Alexander
AU  - Gaiser, Timo
AU  - Brenner, Herrmann
AU  - Chang-Claude, Jenny
AU  - Hoffmeister, Michael
AU  - Jäger, Dirk
AU  - Halama, Niels
TI  - Topography of cancer-associated immune cells in human solid tumors.
JO  - eLife
VL  - 7
SN  - 2050-084X
CY  - Cambridge
PB  - eLife Sciences Publications
M1  - DKFZ-2018-01473
SP  - e36967
PY  - 2018
AB  - Lymphoid and myeloid cells are abundant in the tumor microenvironment, can be quantified by immunohistochemistry and shape the disease course of human solid tumors. Yet, there is no comprehensive understanding of spatial immune infiltration patterns (topography) across cancer entities and across various immune cell types. In this study, we systematically measure the topography of multiple immune cell types in 965 histological tissue slides from N = 177 patients in a pan-cancer cohort. We provide a definition of inflamed (hot), non-inflamed (cold) and immune excluded patterns and investigate how these patterns differ between immune cell types and between cancer types. In an independent cohort of N = 287 colorectal cancer patients, we show that hot, cold and excluded topographies for effector lymphocytes (CD8) and tumor-associated macrophages (CD163) alone are not prognostic, but that a bivariate classification system can stratify patients. Our study adds evidence to consider immune topographies as biomarkers for patients with solid tumors.
LB  - PUB:(DE-HGF)16
C6  - pmid:30179157
C2  - pmc:PMC6133554
DO  - DOI:10.7554/eLife.36967
UR  - https://inrepo02.dkfz.de/record/137593
ER  -