Journal Article

DKFZ-2018-01473

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Topography of cancer-associated immune cells in human solid tumors.

Kather, J. N. (First author)DKFZ* ; Suarez-Carmona, M.DKFZ* ; Charoentong, P.DKFZ* ; Weis, C.-A. ; Hirsch, D. ; Bankhead, P. ; Horning, M. ; Ferber, D. ; Kel, I. ; Herpel, E. ; Schott, S. ; Zörnig, I.DKFZ* ; Utikal, J.DKFZ* ; Marx, A. ; Gaiser, T. ; Brenner, H.DKFZ* ; Chang-Claude, J.DKFZ* ; Hoffmeister, M.DKFZ* ; Jäger, D.DKFZ* ; Halama, N. (Last author)DKFZ*

2018
eLife Sciences Publications Cambridge

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Please use a persistent id in citations: doi:10.7554/eLife.36967

Abstract: Lymphoid and myeloid cells are abundant in the tumor microenvironment, can be quantified by immunohistochemistry and shape the disease course of human solid tumors. Yet, there is no comprehensive understanding of spatial immune infiltration patterns (topography) across cancer entities and across various immune cell types. In this study, we systematically measure the topography of multiple immune cell types in 965 histological tissue slides from N = 177 patients in a pan-cancer cohort. We provide a definition of inflamed (hot), non-inflamed (cold) and immune excluded patterns and investigate how these patterns differ between immune cell types and between cancer types. In an independent cohort of N = 287 colorectal cancer patients, we show that hot, cold and excluded topographies for effector lymphocytes (CD8) and tumor-associated macrophages (CD163) alone are not prognostic, but that a bivariate classification system can stratify patients. Our study adds evidence to consider immune topographies as biomarkers for patients with solid tumors.

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Contributing Institute(s):

1. D120 Angewandte Tumor-Immunität (D120)
2. KKE Dermatoonkologie (G300)
3. C020 Epidemiologie von Krebs (C020)
4. C070 Klinische Epidemiologie und Alternf. (C070)
5. Präventive Onkologie (G110)
6. DKTK Heidelberg (L101)

Research Program(s):

1. 314 - Tumor immunology (POF3-314) (POF3-314)

Appears in the scientific report 2018

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Database coverage:
; ; ; BIOSIS Previews ; DOAJ Seal ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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