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@ARTICLE{Kather:137593,
      author       = {J. N. Kather$^*$ and M. Suarez-Carmona$^*$ and P.
                      Charoentong$^*$ and C.-A. Weis and D. Hirsch and P. Bankhead
                      and M. Horning and D. Ferber and I. Kel and E. Herpel and S.
                      Schott and I. Zörnig$^*$ and J. Utikal$^*$ and A. Marx and
                      T. Gaiser and H. Brenner$^*$ and J. Chang-Claude$^*$ and M.
                      Hoffmeister$^*$ and D. Jäger$^*$ and N. Halama$^*$},
      title        = {{T}opography of cancer-associated immune cells in human
                      solid tumors.},
      journal      = {eLife},
      volume       = {7},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {DKFZ-2018-01473},
      pages        = {e36967},
      year         = {2018},
      abstract     = {Lymphoid and myeloid cells are abundant in the tumor
                      microenvironment, can be quantified by immunohistochemistry
                      and shape the disease course of human solid tumors. Yet,
                      there is no comprehensive understanding of spatial immune
                      infiltration patterns (topography) across cancer entities
                      and across various immune cell types. In this study, we
                      systematically measure the topography of multiple immune
                      cell types in 965 histological tissue slides from N = 177
                      patients in a pan-cancer cohort. We provide a definition of
                      inflamed (hot), non-inflamed (cold) and immune excluded
                      patterns and investigate how these patterns differ between
                      immune cell types and between cancer types. In an
                      independent cohort of N = 287 colorectal cancer patients, we
                      show that hot, cold and excluded topographies for effector
                      lymphocytes (CD8) and tumor-associated macrophages (CD163)
                      alone are not prognostic, but that a bivariate
                      classification system can stratify patients. Our study adds
                      evidence to consider immune topographies as biomarkers for
                      patients with solid tumors.},
      cin          = {D120 / G300 / C020 / C070 / G110 / L101},
      ddc          = {500},
      cid          = {I:(DE-He78)D120-20160331 / I:(DE-He78)G300-20160331 /
                      I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)G110-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30179157},
      pmc          = {pmc:PMC6133554},
      doi          = {10.7554/eLife.36967},
      url          = {https://inrepo02.dkfz.de/record/137593},
}