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000137638 0247_ $$2doi$$a10.2217/epi-2018-0121
000137638 0247_ $$2pmid$$apmid:30208740
000137638 0247_ $$2ISSN$$a1750-1911
000137638 0247_ $$2ISSN$$a1750-192X
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000137638 1001_ $$aBermejo, Justo L$$b0
000137638 245__ $$aLong intergenic noncoding RNA 299 methylation in peripheral blood is a biomarker for triple-negative breast cancer.
000137638 260__ $$aLondon$$bFuture Medicine Ltd.$$c2019
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000137638 520__ $$aTo identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients.We conducted an epigenome-wide association study (EWAS): the most promising markers were identified in 233 TNBC case-control pairs (discovery set) and subsequently validated in an independent validation set (57 TNBC patients and 124 controls).cg06588802 (LINC00299/ID2) showed a higher methylation in TNBC patients compared with controls (discovery set: 3% increase, p-value = 0.0009; validation set: 2% increase, p-value = 0.01). Consistent results at four neighboring methylation probes and the strong negative correlation (rho = -0.93) with LINC00299 expression add plausibility to this result.Hypermethylation of LINC00299 in peripheral blood may constitute a useful circulating biomarker for TNBC.
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000137638 7001_ $$0P:(DE-He78)7f3c83320e010303b656661412554ddf$$aHuang, Guanmengqian$$b1$$udkfz
000137638 7001_ $$0P:(DE-HGF)0$$aManoochehri, Mehdi$$b2
000137638 7001_ $$0P:(DE-HGF)0$$aMesa, Karen G$$b3
000137638 7001_ $$0P:(DE-He78)c954da35a243d177fdc4a3924f4f8a5c$$aSchick, Matthias$$b4
000137638 7001_ $$aSilos, Rosa G$$b5
000137638 7001_ $$aKo, Yon-Dschun$$b6
000137638 7001_ $$aBrüning, Thomas$$b7
000137638 7001_ $$0P:(DE-HGF)0$$aBrauch, Hiltrud$$b8
000137638 7001_ $$aLo, Wing-Yee$$b9
000137638 7001_ $$0P:(DE-He78)c684a26e52cc44716354a4d15f530b4e$$aHoheisel, Jörg$$b10
000137638 7001_ $$0P:(DE-He78)537e07b3e57b16c7b214fc2242e4326b$$aHamann, Ute$$b11$$eLast author
000137638 773__ $$0PERI:(DE-600)2537199-X$$a10.2217/epi-2018-0121$$gp. epi-2018-0121$$n1$$p81-93$$tEpigenomics$$v11$$x1750-192X$$y2019
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