Journal Article

DKFZ-2018-01518

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Long intergenic noncoding RNA 299 methylation in peripheral blood is a biomarker for triple-negative breast cancer.

Bermejo, J. L. ; Huang, G.DKFZ* ; Manoochehri, M.DKFZ* ; Mesa, K. G.DKFZ* ; Schick, M.DKFZ* ; Silos, R. G. ; Ko, Y.-D. ; Brüning, T. ; Brauch, H.DKFZ* ; Lo, W.-Y. ; Hoheisel, J.DKFZ* ; Hamann, U. (Last author)DKFZ*

2019
Future Medicine Ltd. London

This record in other databases:  

Please use a persistent id in citations: doi:10.2217/epi-2018-0121

Abstract: To identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients.We conducted an epigenome-wide association study (EWAS): the most promising markers were identified in 233 TNBC case-control pairs (discovery set) and subsequently validated in an independent validation set (57 TNBC patients and 124 controls).cg06588802 (LINC00299/ID2) showed a higher methylation in TNBC patients compared with controls (discovery set: 3% increase, p-value = 0.0009; validation set: 2% increase, p-value = 0.01). Consistent results at four neighboring methylation probes and the strong negative correlation (rho = -0.93) with LINC00299 expression add plausibility to this result.Hypermethylation of LINC00299 in peripheral blood may constitute a useful circulating biomarker for TNBC.

---

Contributing Institute(s):

1. Molekulargenetik des Mammakarzinoms (B072)
2. Bewerunge-Hudler (W110)
3. DKTK Tübingen (L801)
4. B070 Funktionelle Genomanalyse (B070)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2019

---

Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

---