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@ARTICLE{Bermejo:137638,
      author       = {J. L. Bermejo and G. Huang$^*$ and M. Manoochehri$^*$ and
                      K. G. Mesa$^*$ and M. Schick$^*$ and R. G. Silos and Y.-D.
                      Ko and T. Brüning and H. Brauch$^*$ and W.-Y. Lo and J.
                      Hoheisel$^*$ and U. Hamann$^*$},
      title        = {{L}ong intergenic noncoding {RNA} 299 methylation in
                      peripheral blood is a biomarker for triple-negative breast
                      cancer.},
      journal      = {Epigenomics},
      volume       = {11},
      number       = {1},
      issn         = {1750-192X},
      address      = {London},
      publisher    = {Future Medicine Ltd.},
      reportid     = {DKFZ-2018-01518},
      pages        = {81-93},
      year         = {2019},
      abstract     = {To identify DNA methylation biomarkers in peripheral blood
                      samples from triple-negative breast cancer (TNBC)
                      patients.We conducted an epigenome-wide association study
                      (EWAS): the most promising markers were identified in 233
                      TNBC case-control pairs (discovery set) and subsequently
                      validated in an independent validation set (57 TNBC patients
                      and 124 controls).cg06588802 (LINC00299/ID2) showed a higher
                      methylation in TNBC patients compared with controls
                      (discovery set: $3\%$ increase, p-value = 0.0009;
                      validation set: $2\%$ increase, p-value = 0.01).
                      Consistent results at four neighboring methylation probes
                      and the strong negative correlation (rho = -0.93) with
                      LINC00299 expression add plausibility to this
                      result.Hypermethylation of LINC00299 in peripheral blood may
                      constitute a useful circulating biomarker for TNBC.},
      cin          = {B072 / W110 / L801 / B070},
      ddc          = {570},
      cid          = {I:(DE-He78)B072-20160331 / I:(DE-He78)W110-20160331 /
                      I:(DE-He78)L801-20160331 / I:(DE-He78)B070-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30208740},
      doi          = {10.2217/epi-2018-0121},
      url          = {https://inrepo02.dkfz.de/record/137638},
}