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| 001 | 137638 | ||
| 005 | 20240229112520.0 | ||
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| 100 | 1 | _ | |a Bermejo, Justo L |b 0 |
| 245 | _ | _ | |a Long intergenic noncoding RNA 299 methylation in peripheral blood is a biomarker for triple-negative breast cancer. |
| 260 | _ | _ | |a London |c 2019 |b Future Medicine Ltd. |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a To identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients.We conducted an epigenome-wide association study (EWAS): the most promising markers were identified in 233 TNBC case-control pairs (discovery set) and subsequently validated in an independent validation set (57 TNBC patients and 124 controls).cg06588802 (LINC00299/ID2) showed a higher methylation in TNBC patients compared with controls (discovery set: 3% increase, p-value = 0.0009; validation set: 2% increase, p-value = 0.01). Consistent results at four neighboring methylation probes and the strong negative correlation (rho = -0.93) with LINC00299 expression add plausibility to this result.Hypermethylation of LINC00299 in peripheral blood may constitute a useful circulating biomarker for TNBC. |
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| 700 | 1 | _ | |a Manoochehri, Mehdi |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Mesa, Karen G |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Schick, Matthias |0 P:(DE-He78)c954da35a243d177fdc4a3924f4f8a5c |b 4 |
| 700 | 1 | _ | |a Silos, Rosa G |b 5 |
| 700 | 1 | _ | |a Ko, Yon-Dschun |b 6 |
| 700 | 1 | _ | |a Brüning, Thomas |b 7 |
| 700 | 1 | _ | |a Brauch, Hiltrud |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Lo, Wing-Yee |b 9 |
| 700 | 1 | _ | |a Hoheisel, Jörg |0 P:(DE-He78)c684a26e52cc44716354a4d15f530b4e |b 10 |
| 700 | 1 | _ | |a Hamann, Ute |0 P:(DE-He78)537e07b3e57b16c7b214fc2242e4326b |b 11 |e Last author |
| 773 | _ | _ | |a 10.2217/epi-2018-0121 |g p. epi-2018-0121 |0 PERI:(DE-600)2537199-X |n 1 |p 81-93 |t Epigenomics |v 11 |y 2019 |x 1750-192X |
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