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@ARTICLE{Honda:137681,
      author       = {K. Honda and V. Katzke$^*$ and A. Hüsing$^*$ and S. Okaya
                      and H. Shoji and K. Onidani and A. Olsen and A. Tjønneland
                      and K. Overvad and E. Weiderpass and P. Vineis and D. Muller
                      and K. K. Tsilidis and D. Palli and V. Pala and R. Tumino
                      and A. Naccarati and S. Panico and K. Aleksandrova and H.
                      Boeing and H. B. Bueno-de-Mesquita and P. H. Peeters and A.
                      Trichopoulou and P. Lagiou and K.-T. Khaw and N. J. Wareham
                      and R. C. Travis and S. Merino and E. J. Duell and M.
                      Rodríguez-Barranco and M. D. Chirlaque and A. Barricarte
                      and V. Rebours and M.-C. Boutron-Ruault and F. Romana
                      Mancini and P. Brennan and G. Scelo and J. Manjer and M.
                      Sund and D. Öhlund and F. Canzian$^*$ and R. Kaaks$^*$},
      title        = {{CA}19-9 and {A}polipoprotein-{A}2 isoforms as detection
                      markers for pancreatic cancer - a prospective evaluation.},
      journal      = {International journal of cancer},
      volume       = {144},
      number       = {8},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-01558},
      pages        = {1877-1887},
      year         = {2019},
      abstract     = {Recently, we identified unique processing patterns of
                      apolipoprotein A2 (ApoA2) in patients with pancreatic
                      cancer. This study provides a first prospective evaluation
                      of an ApoA2 isoform ('ApoA2-ATQ/AT'), alone and in
                      combination with carbohydrate antigen 19-9 (CA19-9), as an
                      early detection biomarker for pancreatic cancer. We
                      performed ELISA measurements of CA19-9 and ApoA2-ATQ/AT in
                      156 patients with pancreatic cancer and 217 matched controls
                      within the European EPIC cohort, using plasma samples
                      collected up to 60 months prior to diagnosis. The detection
                      discrimination statistics were calculated for risk scores by
                      strata of lag-time. For CA19-9, in univariate marker
                      analyses, C-statistics to distinguish future pancreatic
                      cancer patients from cancer-free individuals were 0.80 for
                      plasma taken ≤6 months before diagnosis, and 0.71 for
                      >6-18 months; for ApoA2-ATQ/AT, C-statistics were 0.62, and
                      0.65, respectively. Joint models based on ApoA2-ATQ/AT plus
                      CA19-9 significantly improved discrimination within >6-18
                      months (C = 0.74 vs. 0.71 for CA19-9 alone, p = 0.022) and
                      ≤18 months (C = 0.75 vs. 0.74, p = 0.022). At $98\%$
                      specificity, and for lag times of ≤6, >6-18 or ≤18
                      months, sensitivities were $57\%,$ $36\%$ and $43\%$ for
                      CA19-9 combined with ApoA2-ATQ/AT, respectively, vs. $50\%,$
                      $29\%$ and $36\%$ for CA19-9 alone. Compared to CA19-9
                      alone, the combination of CA19-9 and ApoA2-ATQ/AT may
                      improve detection of pancreatic cancer up to 18 months prior
                      to diagnosis under usual care, and may provide a useful
                      first measure for pancreatic cancer detection prior to
                      imaging. This article is protected by copyright. All rights
                      reserved.},
      cin          = {C020 / C055},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C055-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30259989},
      doi          = {10.1002/ijc.31900},
      url          = {https://inrepo02.dkfz.de/record/137681},
}