Journal Article

DKFZ-2018-01558

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png CA19-9 and Apolipoprotein-A2 isoforms as detection markers for pancreatic cancer - a prospective evaluation.

Honda, K. ; Katzke, V.DKFZ* ; Hüsing, A.DKFZ* ; Okaya, S. ; Shoji, H. ; Onidani, K. ; Olsen, A. ; Tjønneland, A. ; Overvad, K. ; Weiderpass, E. ; Vineis, P. ; Muller, D. ; Tsilidis, K. K. ; Palli, D. ; Pala, V. ; Tumino, R. ; Naccarati, A. ; Panico, S. ; Aleksandrova, K. ; Boeing, H. ; Bueno-de-Mesquita, H. B. ; Peeters, P. H. ; Trichopoulou, A. ; Lagiou, P. ; Khaw, K.-T. ; Wareham, N. J. ; Travis, R. C. ; Merino, S. ; Duell, E. J. ; Rodríguez-Barranco, M. ; Chirlaque, M. D. ; Barricarte, A. ; Rebours, V. ; Boutron-Ruault, M.-C. ; Romana Mancini, F. ; Brennan, P. ; Scelo, G. ; Manjer, J. ; Sund, M. ; Öhlund, D. ; Canzian, F.DKFZ* ; Kaaks, R. (Last author)DKFZ*

2019
Wiley-Liss Bognor Regis

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Please use a persistent id in citations: doi:10.1002/ijc.31900

Abstract: Recently, we identified unique processing patterns of apolipoprotein A2 (ApoA2) in patients with pancreatic cancer. This study provides a first prospective evaluation of an ApoA2 isoform ('ApoA2-ATQ/AT'), alone and in combination with carbohydrate antigen 19-9 (CA19-9), as an early detection biomarker for pancreatic cancer. We performed ELISA measurements of CA19-9 and ApoA2-ATQ/AT in 156 patients with pancreatic cancer and 217 matched controls within the European EPIC cohort, using plasma samples collected up to 60 months prior to diagnosis. The detection discrimination statistics were calculated for risk scores by strata of lag-time. For CA19-9, in univariate marker analyses, C-statistics to distinguish future pancreatic cancer patients from cancer-free individuals were 0.80 for plasma taken ≤6 months before diagnosis, and 0.71 for >6-18 months; for ApoA2-ATQ/AT, C-statistics were 0.62, and 0.65, respectively. Joint models based on ApoA2-ATQ/AT plus CA19-9 significantly improved discrimination within >6-18 months (C = 0.74 vs. 0.71 for CA19-9 alone, p = 0.022) and ≤18 months (C = 0.75 vs. 0.74, p = 0.022). At 98% specificity, and for lag times of ≤6, >6-18 or ≤18 months, sensitivities were 57%, 36% and 43% for CA19-9 combined with ApoA2-ATQ/AT, respectively, vs. 50%, 29% and 36% for CA19-9 alone. Compared to CA19-9 alone, the combination of CA19-9 and ApoA2-ATQ/AT may improve detection of pancreatic cancer up to 18 months prior to diagnosis under usual care, and may provide a useful first measure for pancreatic cancer detection prior to imaging. This article is protected by copyright. All rights reserved.

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Contributing Institute(s):

1. Epidemiologie von Krebserkrankungen (C020)
2. Genomische Epidemiologie (C055)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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