Journal Article

DKFZ-2018-01936

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A biobank of patient-derived pediatric brain tumor models.

Brabetz, S. (First author)DKFZ* ; Leary, S. E. S. ; Gröbner, S.DKFZ* ; Nakamoto, M. W. ; Şeker-Cin, H.DKFZ* ; Girard, E. J. ; Cole, B. ; Strand, A. D. ; Bloom, K. L. ; Hovestadt, V.DKFZ* ; Mack, N.DKFZ* ; Pakiam, F. ; Schwalm, B.DKFZ* ; Korshunov, A.DKFZ* ; Balasubramanian, G. P.DKFZ* ; Northcott, P. A.DKFZ* ; Pedro, K. D. ; Dey, J. ; Hansen, S. ; Ditzler, S. ; Lichter, P.DKFZ* ; Chavez, L.DKFZ* ; Jones, D.DKFZ* ; Koster, J. ; Pfister, S.DKFZ* ; Kool, M.DKFZ* ; Olson, J. M.

2018
Nature America Inc. New York, NY

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Please use a persistent id in citations: doi:10.1038/s41591-018-0207-3

Abstract: Brain tumors are the leading cause of cancer-related death in children. Genomic studies have provided insights into molecular subgroups and oncogenic drivers of pediatric brain tumors that may lead to novel therapeutic strategies. To evaluate new treatments, better preclinical models adequately reflecting the biological heterogeneity are needed. Through the Children's Oncology Group ACNS02B3 study, we have generated and comprehensively characterized 30 patient-derived orthotopic xenograft models and seven cell lines representing 14 molecular subgroups of pediatric brain tumors. Patient-derived orthotopic xenograft models were found to be representative of the human tumors they were derived from in terms of histology, immunohistochemistry, gene expression, DNA methylation, copy number, and mutational profiles. In vivo drug sensitivity of targeted therapeutics was associated with distinct molecular tumor subgroups and specific genetic alterations. These models and their molecular characterization provide an unprecedented resource for the cancer community to study key oncogenic drivers and to evaluate novel treatment strategies.

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Contributing Institute(s):

1. B062 Pädiatrische Neuroonkologie (B062)
2. DKTK Heidelberg (L101)
3. B060 Molekulare Genetik (B060)
4. KKE Neuropathologie (G380)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 30 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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