%0 Journal Article
%A Kim, Sehee
%A Wang, Miao
%A Tyrer, Jonathan P
%A Jensen, Allan
%A Wiensch, Ashley
%A Liu, Gang
%A Lee, Alice W
%A Ness, Roberta B
%A Salvatore, Maxwell
%A Tworoger, Shelley S
%A Whittemore, Alice S
%A Anton-Culver, Hoda
%A Sieh, Weiva
%A Olson, Sara H
%A Berchuck, Andrew
%A Goode, Ellen L
%A Goodman, Marc T
%A Doherty, Jennifer Anne
%A Chenevix-Trench, Georgia
%A Rossing, Mary Anne
%A Webb, Penelope M
%A Giles, Graham G
%A Terry, Kathryn L
%A Ziogas, Argyrios
%A Turzanski-Fortner, Renée
%A Menon, Usha
%A Gayther, Simon A
%A Wu, Anna H
%A Song, Honglin
%A Brooks-Wilson, Angela
%A Bandera, Elisa V
%A Cook, Linda S
%A Cramer, Daniel W
%A Milne, Roger L
%A Winham, Stacey J
%A Kjaer, Susanne K
%A Modugno, Francesmary
%A Thompson, Pamela J
%A Chang-Claude, Jenny
%A Harris, Holly R
%A Schildkraut, Joellen M
%A Le, Nhu D
%A Wentzensen, Nico
%A Trabert, Britton
%A Høgdall, Estrid
%A Huntsman, David
%A Pike, Malcolm C
%A Pharoah, Paul D P
%A Pearce, Celeste Leigh
%A Mukherjee, Bhramar
%T A Comprehensive Gene-Environment Interaction Analysis in Ovarian Cancer using Genome-wide Significant Common Variants.
%J International journal of cancer
%V 144
%N 9
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2018-02077
%P 2192-2205
%D 2019
%X As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), this study considers seven well-known ovarian cancer risk factors and their interactions with 28 genome-wide significant common genetic variants. The interaction analyses were based on data from 9,971 ovarian cancer cases and 15,566 controls from 17 case-control studies. Likelihood ratio and Wald tests for multiplicative interaction and for relative excess risk due to additive interaction were used. The top multiplicative interaction was noted between oral contraceptive pill (OCP) use (ever vs never) and rs13255292 (P-value = 3.48 x 10-4 ). Among women with the TT genotype for this variant, the odds ratio for OCP use was 0.53 (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30499236
%R 10.1002/ijc.32029
%U https://inrepo02.dkfz.de/record/141809