Journal Article

DKFZ-2018-02077

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A Comprehensive Gene-Environment Interaction Analysis in Ovarian Cancer using Genome-wide Significant Common Variants.

Kim, S. ; Wang, M. ; Tyrer, J. P. ; Jensen, A. ; Wiensch, A. ; Liu, G. ; Lee, A. W. ; Ness, R. B. ; Salvatore, M. ; Tworoger, S. S. ; Whittemore, A. S. ; Anton-Culver, H. ; Sieh, W. ; Olson, S. H. ; Berchuck, A. ; Goode, E. L. ; Goodman, M. T. ; Doherty, J. A. ; Chenevix-Trench, G. ; Rossing, M. A. ; Webb, P. M. ; Giles, G. G. ; Terry, K. L. ; Ziogas, A. ; Turzanski-Fortner, R.DKFZ* ; Menon, U. ; Gayther, S. A. ; Wu, A. H. ; Song, H. ; Brooks-Wilson, A. ; Bandera, E. V. ; Cook, L. S. ; Cramer, D. W. ; Milne, R. L. ; Winham, S. J. ; Kjaer, S. K. ; Modugno, F. ; Thompson, P. J. ; Chang-Claude, J.DKFZ* ; Harris, H. R. ; Schildkraut, J. M. ; Le, N. D. ; Wentzensen, N. ; Trabert, B. ; Høgdall, E. ; Huntsman, D. ; Pike, M. C. ; Pharoah, P. D. P. ; Pearce, C. L. ; Mukherjee, B.

2019
Wiley-Liss Bognor Regis

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/ijc.32029

Abstract: As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), this study considers seven well-known ovarian cancer risk factors and their interactions with 28 genome-wide significant common genetic variants. The interaction analyses were based on data from 9,971 ovarian cancer cases and 15,566 controls from 17 case-control studies. Likelihood ratio and Wald tests for multiplicative interaction and for relative excess risk due to additive interaction were used. The top multiplicative interaction was noted between oral contraceptive pill (OCP) use (ever vs never) and rs13255292 (P-value = 3.48 x 10-4 ). Among women with the TT genotype for this variant, the odds ratio for OCP use was 0.53 (95% CI=0.46-0.60) compared to 0.71 (95%CI=0.66-0.77) for women with the CC genotype. When stratified by duration of OCP use, women with 1-5 years of OCP use exhibited differential protective benefit across genotypes. However, no interaction on either the multiplicative or additive scale was found to be statistically significant after multiple testing correction. The results suggest that OCP use may offer increased benefit for women who are carriers of the T allele in rs13255292. On the other hand, for women carrying the C allele in this variant, longer (5+ years) use of OCP may reduce the impact of carrying the risk allele of this SNP. Replication of this finding is needed. The study presents a comprehensive analytic framework for conducting gene-environment analysis in ovarian cancer. This article is protected by copyright. All rights reserved.

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Contributing Institute(s):

1. Epidemiologie von Krebserkrankungen (C020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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