TY  - JOUR
AU  - Kim, Sehee
AU  - Wang, Miao
AU  - Tyrer, Jonathan P
AU  - Jensen, Allan
AU  - Wiensch, Ashley
AU  - Liu, Gang
AU  - Lee, Alice W
AU  - Ness, Roberta B
AU  - Salvatore, Maxwell
AU  - Tworoger, Shelley S
AU  - Whittemore, Alice S
AU  - Anton-Culver, Hoda
AU  - Sieh, Weiva
AU  - Olson, Sara H
AU  - Berchuck, Andrew
AU  - Goode, Ellen L
AU  - Goodman, Marc T
AU  - Doherty, Jennifer Anne
AU  - Chenevix-Trench, Georgia
AU  - Rossing, Mary Anne
AU  - Webb, Penelope M
AU  - Giles, Graham G
AU  - Terry, Kathryn L
AU  - Ziogas, Argyrios
AU  - Turzanski-Fortner, Renée
AU  - Menon, Usha
AU  - Gayther, Simon A
AU  - Wu, Anna H
AU  - Song, Honglin
AU  - Brooks-Wilson, Angela
AU  - Bandera, Elisa V
AU  - Cook, Linda S
AU  - Cramer, Daniel W
AU  - Milne, Roger L
AU  - Winham, Stacey J
AU  - Kjaer, Susanne K
AU  - Modugno, Francesmary
AU  - Thompson, Pamela J
AU  - Chang-Claude, Jenny
AU  - Harris, Holly R
AU  - Schildkraut, Joellen M
AU  - Le, Nhu D
AU  - Wentzensen, Nico
AU  - Trabert, Britton
AU  - Høgdall, Estrid
AU  - Huntsman, David
AU  - Pike, Malcolm C
AU  - Pharoah, Paul D P
AU  - Pearce, Celeste Leigh
AU  - Mukherjee, Bhramar
TI  - A Comprehensive Gene-Environment Interaction Analysis in Ovarian Cancer using Genome-wide Significant Common Variants.
JO  - International journal of cancer
VL  - 144
IS  - 9
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2018-02077
SP  - 2192-2205
PY  - 2019
AB  - As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), this study considers seven well-known ovarian cancer risk factors and their interactions with 28 genome-wide significant common genetic variants. The interaction analyses were based on data from 9,971 ovarian cancer cases and 15,566 controls from 17 case-control studies. Likelihood ratio and Wald tests for multiplicative interaction and for relative excess risk due to additive interaction were used. The top multiplicative interaction was noted between oral contraceptive pill (OCP) use (ever vs never) and rs13255292 (P-value = 3.48 x 10-4 ). Among women with the TT genotype for this variant, the odds ratio for OCP use was 0.53 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:30499236
DO  - DOI:10.1002/ijc.32029
UR  - https://inrepo02.dkfz.de/record/141809
ER  -