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@ARTICLE{Kim:141809,
      author       = {S. Kim and M. Wang and J. P. Tyrer and A. Jensen and A.
                      Wiensch and G. Liu and A. W. Lee and R. B. Ness and M.
                      Salvatore and S. S. Tworoger and A. S. Whittemore and H.
                      Anton-Culver and W. Sieh and S. H. Olson and A. Berchuck and
                      E. L. Goode and M. T. Goodman and J. A. Doherty and G.
                      Chenevix-Trench and M. A. Rossing and P. M. Webb and G. G.
                      Giles and K. L. Terry and A. Ziogas and R.
                      Turzanski-Fortner$^*$ and U. Menon and S. A. Gayther and A.
                      H. Wu and H. Song and A. Brooks-Wilson and E. V. Bandera and
                      L. S. Cook and D. W. Cramer and R. L. Milne and S. J. Winham
                      and S. K. Kjaer and F. Modugno and P. J. Thompson and J.
                      Chang-Claude$^*$ and H. R. Harris and J. M. Schildkraut and
                      N. D. Le and N. Wentzensen and B. Trabert and E. Høgdall
                      and D. Huntsman and M. C. Pike and P. D. P. Pharoah and C.
                      L. Pearce and B. Mukherjee},
      title        = {{A} {C}omprehensive {G}ene-{E}nvironment {I}nteraction
                      {A}nalysis in {O}varian {C}ancer using {G}enome-wide
                      {S}ignificant {C}ommon {V}ariants.},
      journal      = {International journal of cancer},
      volume       = {144},
      number       = {9},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-02077},
      pages        = {2192-2205},
      year         = {2019},
      abstract     = {As a follow-up to genome-wide association analysis of
                      common variants associated with ovarian carcinoma (cancer),
                      this study considers seven well-known ovarian cancer risk
                      factors and their interactions with 28 genome-wide
                      significant common genetic variants. The interaction
                      analyses were based on data from 9,971 ovarian cancer cases
                      and 15,566 controls from 17 case-control studies. Likelihood
                      ratio and Wald tests for multiplicative interaction and for
                      relative excess risk due to additive interaction were used.
                      The top multiplicative interaction was noted between oral
                      contraceptive pill (OCP) use (ever vs never) and rs13255292
                      (P-value = 3.48 x 10-4 ). Among women with the TT genotype
                      for this variant, the odds ratio for OCP use was 0.53
                      $(95\%$ CI=0.46-0.60) compared to 0.71 $(95\%CI=0.66-0.77)$
                      for women with the CC genotype. When stratified by duration
                      of OCP use, women with 1-5 years of OCP use exhibited
                      differential protective benefit across genotypes. However,
                      no interaction on either the multiplicative or additive
                      scale was found to be statistically significant after
                      multiple testing correction. The results suggest that OCP
                      use may offer increased benefit for women who are carriers
                      of the T allele in rs13255292. On the other hand, for women
                      carrying the C allele in this variant, longer (5+ years) use
                      of OCP may reduce the impact of carrying the risk allele of
                      this SNP. Replication of this finding is needed. The study
                      presents a comprehensive analytic framework for conducting
                      gene-environment analysis in ovarian cancer. This article is
                      protected by copyright. All rights reserved.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30499236},
      doi          = {10.1002/ijc.32029},
      url          = {https://inrepo02.dkfz.de/record/141809},
}