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000141900 041__ $$aeng
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000141900 1001_ $$0P:(DE-HGF)0$$aWinter, Julia$$b0$$eFirst author
000141900 245__ $$aMany roads to maturity: microRNA biogenesis pathways and their regulation.
000141900 260__ $$aNew York, NY$$bNature America$$c2009
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000141900 520__ $$aMicroRNAs are important regulators of gene expression that control both physiological and pathological processes such as development and cancer. Although their mode of action has attracted great attention, the principles governing their expression and activity are only beginning to emerge. Recent studies have introduced a paradigm shift in our understanding of the microRNA biogenesis pathway, which was previously believed to be universal to all microRNAs. Maturation steps specific to individual microRNAs have been uncovered, and these offer a plethora of regulatory options after transcription with multiple proteins affecting microRNA processing efficiency. Here we review the recent advances in knowledge of the microRNA biosynthesis pathways and discuss their impact on post-transcriptional microRNA regulation during tumour development.
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000141900 650_7 $$2NLM Chemicals$$aMicroRNAs
000141900 650_7 $$2NLM Chemicals$$aRNA Precursors
000141900 7001_ $$0P:(DE-HGF)0$$aJung, Stephanie$$b1
000141900 7001_ $$0P:(DE-HGF)0$$aKeller, Sarina$$b2
000141900 7001_ $$aGregory, Richard I$$b3
000141900 7001_ $$0P:(DE-He78)93eb54ede184de6f9de29d827ffb27f6$$aDiederichs, Sven$$b4$$eLast author$$udkfz
000141900 773__ $$0PERI:(DE-600)1494945-3$$a10.1038/ncb0309-228$$gVol. 11, no. 3, p. 228 - 234$$n3$$p228 - 234$$tNature cell biology$$v11$$x1476-4679$$y2009
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