Journal Article (Review Article)

DKFZ-2018-02157

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Many roads to maturity: microRNA biogenesis pathways and their regulation.

Winter, J. (First author)DKFZ* ; Jung, S.DKFZ* ; Keller, S.DKFZ* ; Gregory, R. I. ; Diederichs, S. (Last author)DKFZ*

2009
Nature America New York, NY

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Please use a persistent id in citations: doi:10.1038/ncb0309-228

Abstract: MicroRNAs are important regulators of gene expression that control both physiological and pathological processes such as development and cancer. Although their mode of action has attracted great attention, the principles governing their expression and activity are only beginning to emerge. Recent studies have introduced a paradigm shift in our understanding of the microRNA biogenesis pathway, which was previously believed to be universal to all microRNAs. Maturation steps specific to individual microRNAs have been uncovered, and these offer a plethora of regulatory options after transcription with multiple proteins affecting microRNA processing efficiency. Here we review the recent advances in knowledge of the microRNA biosynthesis pathways and discuss their impact on post-transcriptional microRNA regulation during tumour development.

Keyword(s): MicroRNAs ; RNA Precursors

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Contributing Institute(s):

1. RNA-Biologie und Krebs (B150)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2009

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 15 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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