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@ARTICLE{Winter:141900,
      author       = {J. Winter$^*$ and S. Jung$^*$ and S. Keller$^*$ and R. I.
                      Gregory and S. Diederichs$^*$},
      title        = {{M}any roads to maturity: micro{RNA} biogenesis pathways
                      and their regulation.},
      journal      = {Nature cell biology},
      volume       = {11},
      number       = {3},
      issn         = {1476-4679},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {DKFZ-2018-02157},
      pages        = {228 - 234},
      year         = {2009},
      abstract     = {MicroRNAs are important regulators of gene expression that
                      control both physiological and pathological processes such
                      as development and cancer. Although their mode of action has
                      attracted great attention, the principles governing their
                      expression and activity are only beginning to emerge. Recent
                      studies have introduced a paradigm shift in our
                      understanding of the microRNA biogenesis pathway, which was
                      previously believed to be universal to all microRNAs.
                      Maturation steps specific to individual microRNAs have been
                      uncovered, and these offer a plethora of regulatory options
                      after transcription with multiple proteins affecting
                      microRNA processing efficiency. Here we review the recent
                      advances in knowledge of the microRNA biosynthesis pathways
                      and discuss their impact on post-transcriptional microRNA
                      regulation during tumour development.},
      subtyp        = {Review Article},
      keywords     = {MicroRNAs (NLM Chemicals) / RNA Precursors (NLM Chemicals)},
      cin          = {B150},
      ddc          = {570},
      cid          = {I:(DE-He78)B150-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19255566},
      doi          = {10.1038/ncb0309-228},
      url          = {https://inrepo02.dkfz.de/record/141900},
}