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@ARTICLE{Brenz:141980,
      author       = {F. Bärenz$^*$ and Y. T. Kschonsak$^*$ and A. Meyer$^*$ and
                      A. Jafarpour and H. Lorenz and I. Hoffmann$^*$},
      title        = {{C}cdc61 controls centrosomal localization of {C}ep170 and
                      is required for spindle assembly and symmetry.},
      journal      = {Molecular biology of the cell},
      volume       = {29},
      number       = {26},
      issn         = {1939-4586},
      address      = {Bethesda, Md.},
      publisher    = {American Society for Cell Biology},
      reportid     = {DKFZ-2018-02210},
      pages        = {3105 - 3118},
      year         = {2018},
      abstract     = {Microtubule nucleation was uncovered as a key principle of
                      spindle assembly. However, the mechanistic details about
                      microtubule nucleation and the organization of spindle
                      formation and symmetry are currently being revealed. Here we
                      describe the function of Coiled-coil domain containing 61
                      (Ccdc61), a so far uncharacterized centrosomal protein, in
                      spindle assembly and symmetry. Our data describe that Ccdc61
                      is required for spindle assembly and precise chromosome
                      alignments in mitosis. Microtubule tip-tracking experiments
                      in the absence of Ccdc61 reveal a clear loss of the
                      intrinsic symmetry of microtubule tracks within the spindle.
                      Furthermore, we show that Ccdc61 controls the centrosomal
                      localization of Cep170, a protein that was shown previously
                      to localize to centrosomes as well as spindle microtubules
                      and promotes microtubule organization and microtubule
                      assembly. Interestingly, selective disruption of Ccdc61
                      impairs the binding between Cep170 and TBK1, an interaction
                      that is required for microtubule stability. In summary, we
                      have discovered Ccdc61 as a centrosomal protein with an
                      important function in mitotic microtubule organization.
                      [Media: see text] [Media: see text] [Media: see text]
                      [Media: see text] [Media: see text] [Media: see text].},
      cin          = {F045},
      ddc          = {570},
      cid          = {I:(DE-He78)F045-20160331},
      pnm          = {316 - Infections and cancer (POF3-316)},
      pid          = {G:(DE-HGF)POF3-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30354798},
      doi          = {10.1091/mbc.E18-02-0115},
      url          = {https://inrepo02.dkfz.de/record/141980},
}