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000142034 0247_ $$2doi$$a10.1016/j.ccell.2018.10.016
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000142034 1001_ $$0P:(DE-He78)3c4679d03b730156fae20c4948722efe$$aGerhäuser, Clarissa$$b0$$eFirst author
000142034 245__ $$aMolecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories.
000142034 260__ $$aNew York, NY$$bElsevier$$c2018
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000142034 520__ $$aIdentifying the earliest somatic changes in prostate cancer can give important insights into tumor evolution and aids in stratifying high- from low-risk disease. We integrated whole genome, transcriptome and methylome analysis of early-onset prostate cancers (diagnosis ≤55 years). Characterization across 292 prostate cancer genomes revealed age-related genomic alterations and a clock-like enzymatic-driven mutational process contributing to the earliest mutations in prostate cancer patients. Our integrative analysis identified four molecular subgroups, including a particularly aggressive subgroup with recurrent duplications associated with increased expression of ESRP1, which we validate in 12,000 tissue microarray tumors. Finally, we combined the patterns of molecular co-occurrence and risk-based subgroup information to deconvolve the molecular and clinical trajectories of prostate cancer from single patient samples.
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000142034 7001_ $$0P:(DE-He78)165f8880edf86f16a4db22df31bf0212$$aFavero, Francesco$$b1$$eFirst author$$udkfz
000142034 7001_ $$aRisch, Thomas$$b2
000142034 7001_ $$aSimon, Ronald$$b3
000142034 7001_ $$0P:(DE-He78)75e2afb3ea0812786cc551c10679b67d$$aFeuerbach, Lars$$b4$$eFirst author
000142034 7001_ $$0P:(DE-He78)45a6854ecf41ba2e65ca3ba0d560f14c$$aAssenov, Yassen$$b5$$eFirst author
000142034 7001_ $$0P:(DE-He78)98dd16a42af0888dd129e1cd2ee2766a$$aHeckmann, Doreen$$b6$$eFirst author
000142034 7001_ $$aSidiropoulos, Nikos$$b7
000142034 7001_ $$aWaszak, Sebastian M$$b8
000142034 7001_ $$aHübschmann, Daniel$$b9
000142034 7001_ $$aUrbanucci, Alfonso$$b10
000142034 7001_ $$aGirma, Etsehiwot G$$b11
000142034 7001_ $$0P:(DE-He78)cd1568106ba01cc0741f464d15267a9b$$aKuryshev, Vladimir$$b12
000142034 7001_ $$aKlimczak, Leszek J$$b13
000142034 7001_ $$aSaini, Natalie$$b14
000142034 7001_ $$aStütz, Adrian M$$b15
000142034 7001_ $$0P:(DE-He78)ff4024f7bc236e7897d9c18ee19c451f$$aWeichenhan, Dieter$$b16
000142034 7001_ $$aBöttcher, Lisa-Marie$$b17
000142034 7001_ $$0P:(DE-He78)cd2ec3f2ae9b2178f113e0f2ed15fc48$$aToth, Reka$$b18
000142034 7001_ $$aHendriksen, Josephine D$$b19
000142034 7001_ $$aKoop, Christina$$b20
000142034 7001_ $$0P:(DE-He78)ff1677c63392be9b31a1c8d23db7c9dc$$aLutsik, Pavlo$$b21
000142034 7001_ $$aMatzk, Sören$$b22
000142034 7001_ $$aWarnatz, Hans-Jörg$$b23
000142034 7001_ $$aAmstislavskiy, Vyacheslav$$b24
000142034 7001_ $$0P:(DE-He78)49a2ee7fd798ba65792874ed2aed1b10$$aFeuerstein, Clarissa$$b25
000142034 7001_ $$aRaeder, Benjamin$$b26
000142034 7001_ $$0P:(DE-He78)3493620cedb8f0b17c9e1b424c0e21db$$aBogatyrova, Olga$$b27
000142034 7001_ $$aSchmitz, Eva-Maria$$b28
000142034 7001_ $$aHube-Magg, Claudia$$b29
000142034 7001_ $$aKluth, Martina$$b30
000142034 7001_ $$aHuland, Hartwig$$b31
000142034 7001_ $$aGraefen, Markus$$b32
000142034 7001_ $$0P:(DE-He78)5398550c21bc4ce3b0ff670b04150334$$aLawerenz, Christian$$b33
000142034 7001_ $$aHenry, Gervaise H$$b34
000142034 7001_ $$aYamaguchi, Takafumi N$$b35
000142034 7001_ $$aMalewska, Alicia$$b36
000142034 7001_ $$aMeiners, Jan$$b37
000142034 7001_ $$0P:(DE-He78)f2433a95a08506a024f9e91d6129b595$$aSchilling, Daniela$$b38
000142034 7001_ $$0P:(DE-He78)63ceb91f3d4f8750e9e1b4967d6aab75$$aReisinger, Eva-Maria$$b39
000142034 7001_ $$0P:(DE-He78)78b6aa82148e60b4d91e3a37a6d3d9a0$$aEils, Roland$$b40
000142034 7001_ $$0P:(DE-He78)f2a782242acf94a3114d75c45dc75b37$$aSchlesner, Matthias$$b41
000142034 7001_ $$aStrand, Douglas W$$b42
000142034 7001_ $$aBristow, Robert G$$b43
000142034 7001_ $$aBoutros, Paul C$$b44
000142034 7001_ $$0P:(DE-He78)5bacb661d5d7c0220d8f996d980ad8de$$avon Kalle, Christof$$b45
000142034 7001_ $$aGordenin, Dmitry$$b46
000142034 7001_ $$0P:(DE-He78)7483734fd8ab316391aa604c95f0e98a$$aSültmann, Holger$$b47$$eLast author
000142034 7001_ $$0P:(DE-He78)fc949170377b58098e46141d95c72661$$aBrors, Benedikt$$b48$$eLast author
000142034 7001_ $$aSauter, Guido$$b49
000142034 7001_ $$0P:(DE-He78)4301875630bc997edf491c694ae1f8a9$$aPlass, Christoph$$b50$$eLast author
000142034 7001_ $$aYaspo, Marie-Laure$$b51
000142034 7001_ $$0P:(DE-He78)372b77c2acf8604690a6a325a4e89287$$aKorbel, Jan O$$b52$$eLast author$$udkfz
000142034 7001_ $$aSchlomm, Thorsten$$b53
000142034 7001_ $$aWeischenfeldt, Joachim$$b54
000142034 773__ $$0PERI:(DE-600)2074034-7$$a10.1016/j.ccell.2018.10.016$$gVol. 34, no. 6, p. 996 - 1011.e8$$n6$$p996 - 1011.e8$$tCancer cell$$v34$$x1535-6108$$y2018
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