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@ARTICLE{Gerhuser:142034,
      author       = {C. Gerhäuser$^*$ and F. Favero$^*$ and T. Risch and R.
                      Simon and L. Feuerbach$^*$ and Y. Assenov$^*$ and D.
                      Heckmann$^*$ and N. Sidiropoulos and S. M. Waszak and D.
                      Hübschmann and A. Urbanucci and E. G. Girma and V.
                      Kuryshev$^*$ and L. J. Klimczak and N. Saini and A. M.
                      Stütz and D. Weichenhan$^*$ and L.-M. Böttcher and R.
                      Toth$^*$ and J. D. Hendriksen and C. Koop and P. Lutsik$^*$
                      and S. Matzk and H.-J. Warnatz and V. Amstislavskiy and C.
                      Feuerstein$^*$ and B. Raeder and O. Bogatyrova$^*$ and E.-M.
                      Schmitz and C. Hube-Magg and M. Kluth and H. Huland and M.
                      Graefen and C. Lawerenz$^*$ and G. H. Henry and T. N.
                      Yamaguchi and A. Malewska and J. Meiners and D.
                      Schilling$^*$ and E.-M. Reisinger$^*$ and R. Eils$^*$ and M.
                      Schlesner$^*$ and D. W. Strand and R. G. Bristow and P. C.
                      Boutros and C. von Kalle$^*$ and D. Gordenin and H.
                      Sültmann$^*$ and B. Brors$^*$ and G. Sauter and C.
                      Plass$^*$ and M.-L. Yaspo and J. O. Korbel$^*$ and T.
                      Schlomm and J. Weischenfeldt},
      title        = {{M}olecular {E}volution of {E}arly-{O}nset {P}rostate
                      {C}ancer {I}dentifies {M}olecular {R}isk {M}arkers and
                      {C}linical {T}rajectories.},
      journal      = {Cancer cell},
      volume       = {34},
      number       = {6},
      issn         = {1535-6108},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2018-02264},
      pages        = {996 - 1011.e8},
      year         = {2018},
      abstract     = {Identifying the earliest somatic changes in prostate cancer
                      can give important insights into tumor evolution and aids in
                      stratifying high- from low-risk disease. We integrated whole
                      genome, transcriptome and methylome analysis of early-onset
                      prostate cancers (diagnosis ≤55 years). Characterization
                      across 292 prostate cancer genomes revealed age-related
                      genomic alterations and a clock-like enzymatic-driven
                      mutational process contributing to the earliest mutations in
                      prostate cancer patients. Our integrative analysis
                      identified four molecular subgroups, including a
                      particularly aggressive subgroup with recurrent duplications
                      associated with increased expression of ESRP1, which we
                      validate in 12,000 tissue microarray tumors. Finally, we
                      combined the patterns of molecular co-occurrence and
                      risk-based subgroup information to deconvolve the molecular
                      and clinical trajectories of prostate cancer from single
                      patient samples.},
      cin          = {C010 / G200 / B063 / L101 / B080 / B240},
      ddc          = {610},
      cid          = {I:(DE-He78)C010-20160331 / I:(DE-He78)G200-20160331 /
                      I:(DE-He78)B063-20160331 / I:(DE-He78)L101-20160331 /
                      I:(DE-He78)B080-20160331 / I:(DE-He78)B240-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30537516},
      doi          = {10.1016/j.ccell.2018.10.016},
      url          = {https://inrepo02.dkfz.de/record/142034},
}