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| 001 | 142034 | ||
| 005 | 20240229105140.0 | ||
| 024 | 7 | _ | |a 10.1016/j.ccell.2018.10.016 |2 doi |
| 024 | 7 | _ | |a pmid:30537516 |2 pmid |
| 024 | 7 | _ | |a 1535-6108 |2 ISSN |
| 024 | 7 | _ | |a 1878-3686 |2 ISSN |
| 024 | 7 | _ | |a altmetric:52470368 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2018-02264 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Gerhäuser, Clarissa |0 P:(DE-He78)3c4679d03b730156fae20c4948722efe |b 0 |e First author |
| 245 | _ | _ | |a Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories. |
| 260 | _ | _ | |a New York, NY |c 2018 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1680781025_21947 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Identifying the earliest somatic changes in prostate cancer can give important insights into tumor evolution and aids in stratifying high- from low-risk disease. We integrated whole genome, transcriptome and methylome analysis of early-onset prostate cancers (diagnosis ≤55 years). Characterization across 292 prostate cancer genomes revealed age-related genomic alterations and a clock-like enzymatic-driven mutational process contributing to the earliest mutations in prostate cancer patients. Our integrative analysis identified four molecular subgroups, including a particularly aggressive subgroup with recurrent duplications associated with increased expression of ESRP1, which we validate in 12,000 tissue microarray tumors. Finally, we combined the patterns of molecular co-occurrence and risk-based subgroup information to deconvolve the molecular and clinical trajectories of prostate cancer from single patient samples. |
| 536 | _ | _ | |a 313 - Cancer risk factors and prevention (POF3-313) |0 G:(DE-HGF)POF3-313 |c POF3-313 |f POF III |x 0 |
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| 700 | 1 | _ | |a Favero, Francesco |0 P:(DE-He78)165f8880edf86f16a4db22df31bf0212 |b 1 |e First author |u dkfz |
| 700 | 1 | _ | |a Risch, Thomas |b 2 |
| 700 | 1 | _ | |a Simon, Ronald |b 3 |
| 700 | 1 | _ | |a Feuerbach, Lars |0 P:(DE-He78)75e2afb3ea0812786cc551c10679b67d |b 4 |e First author |
| 700 | 1 | _ | |a Assenov, Yassen |0 P:(DE-He78)45a6854ecf41ba2e65ca3ba0d560f14c |b 5 |e First author |
| 700 | 1 | _ | |a Heckmann, Doreen |0 P:(DE-He78)98dd16a42af0888dd129e1cd2ee2766a |b 6 |e First author |
| 700 | 1 | _ | |a Sidiropoulos, Nikos |b 7 |
| 700 | 1 | _ | |a Waszak, Sebastian M |b 8 |
| 700 | 1 | _ | |a Hübschmann, Daniel |b 9 |
| 700 | 1 | _ | |a Urbanucci, Alfonso |b 10 |
| 700 | 1 | _ | |a Girma, Etsehiwot G |b 11 |
| 700 | 1 | _ | |a Kuryshev, Vladimir |0 P:(DE-He78)cd1568106ba01cc0741f464d15267a9b |b 12 |
| 700 | 1 | _ | |a Klimczak, Leszek J |b 13 |
| 700 | 1 | _ | |a Saini, Natalie |b 14 |
| 700 | 1 | _ | |a Stütz, Adrian M |b 15 |
| 700 | 1 | _ | |a Weichenhan, Dieter |0 P:(DE-He78)ff4024f7bc236e7897d9c18ee19c451f |b 16 |
| 700 | 1 | _ | |a Böttcher, Lisa-Marie |b 17 |
| 700 | 1 | _ | |a Toth, Reka |0 P:(DE-He78)cd2ec3f2ae9b2178f113e0f2ed15fc48 |b 18 |
| 700 | 1 | _ | |a Hendriksen, Josephine D |b 19 |
| 700 | 1 | _ | |a Koop, Christina |b 20 |
| 700 | 1 | _ | |a Lutsik, Pavlo |0 P:(DE-He78)ff1677c63392be9b31a1c8d23db7c9dc |b 21 |
| 700 | 1 | _ | |a Matzk, Sören |b 22 |
| 700 | 1 | _ | |a Warnatz, Hans-Jörg |b 23 |
| 700 | 1 | _ | |a Amstislavskiy, Vyacheslav |b 24 |
| 700 | 1 | _ | |a Feuerstein, Clarissa |0 P:(DE-He78)49a2ee7fd798ba65792874ed2aed1b10 |b 25 |
| 700 | 1 | _ | |a Raeder, Benjamin |b 26 |
| 700 | 1 | _ | |a Bogatyrova, Olga |0 P:(DE-He78)3493620cedb8f0b17c9e1b424c0e21db |b 27 |
| 700 | 1 | _ | |a Schmitz, Eva-Maria |b 28 |
| 700 | 1 | _ | |a Hube-Magg, Claudia |b 29 |
| 700 | 1 | _ | |a Kluth, Martina |b 30 |
| 700 | 1 | _ | |a Huland, Hartwig |b 31 |
| 700 | 1 | _ | |a Graefen, Markus |b 32 |
| 700 | 1 | _ | |a Lawerenz, Christian |0 P:(DE-He78)5398550c21bc4ce3b0ff670b04150334 |b 33 |
| 700 | 1 | _ | |a Henry, Gervaise H |b 34 |
| 700 | 1 | _ | |a Yamaguchi, Takafumi N |b 35 |
| 700 | 1 | _ | |a Malewska, Alicia |b 36 |
| 700 | 1 | _ | |a Meiners, Jan |b 37 |
| 700 | 1 | _ | |a Schilling, Daniela |0 P:(DE-He78)f2433a95a08506a024f9e91d6129b595 |b 38 |
| 700 | 1 | _ | |a Reisinger, Eva-Maria |0 P:(DE-He78)63ceb91f3d4f8750e9e1b4967d6aab75 |b 39 |
| 700 | 1 | _ | |a Eils, Roland |0 P:(DE-He78)78b6aa82148e60b4d91e3a37a6d3d9a0 |b 40 |
| 700 | 1 | _ | |a Schlesner, Matthias |0 P:(DE-He78)f2a782242acf94a3114d75c45dc75b37 |b 41 |
| 700 | 1 | _ | |a Strand, Douglas W |b 42 |
| 700 | 1 | _ | |a Bristow, Robert G |b 43 |
| 700 | 1 | _ | |a Boutros, Paul C |b 44 |
| 700 | 1 | _ | |a von Kalle, Christof |0 P:(DE-He78)5bacb661d5d7c0220d8f996d980ad8de |b 45 |
| 700 | 1 | _ | |a Gordenin, Dmitry |b 46 |
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| 700 | 1 | _ | |a Brors, Benedikt |0 P:(DE-He78)fc949170377b58098e46141d95c72661 |b 48 |e Last author |
| 700 | 1 | _ | |a Sauter, Guido |b 49 |
| 700 | 1 | _ | |a Plass, Christoph |0 P:(DE-He78)4301875630bc997edf491c694ae1f8a9 |b 50 |e Last author |
| 700 | 1 | _ | |a Yaspo, Marie-Laure |b 51 |
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| 700 | 1 | _ | |a Schlomm, Thorsten |b 53 |
| 700 | 1 | _ | |a Weischenfeldt, Joachim |b 54 |
| 773 | _ | _ | |a 10.1016/j.ccell.2018.10.016 |g Vol. 34, no. 6, p. 996 - 1011.e8 |0 PERI:(DE-600)2074034-7 |n 6 |p 996 - 1011.e8 |t Cancer cell |v 34 |y 2018 |x 1535-6108 |
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