%0 Journal Article
%A Lipka, Daniel
%A Lutsik, Pavlo
%A Plass, Christoph
%T From Basic Knowledge to Effective Therapies.
%J Cancer cell
%V 34
%N 6
%@ 1535-6108
%C New York, NY
%I Elsevier
%M DKFZ-2019-00192
%P 871 - 873
%D 2018
%X In this issue of Cancer Cell, Ott et al. use integrative analysis of histone ChIP-seq and ATAC-seq to describe enhancer-based regulatory circuits in chronic lymphocytic leukemia. This work identified and validated transcription factor PAX5 as main driver of an oncogenic circuitry, which can be disrupted by BET bromodomain inhibition.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30537508
%R 10.1016/j.ccell.2018.11.013
%U https://inrepo02.dkfz.de/record/142473