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@ARTICLE{Yudhistiara:142852,
      author       = {B. Yudhistiara and F. Zwicker$^*$ and K. J. Weber and P.
                      Huber$^*$ and A. Ruehle$^*$ and S. Brons and P. Haering$^*$
                      and J. Debus$^*$ and S. H. Hauswald$^*$},
      title        = {{T}he influence of a magnetic field on photon beam
                      radiotherapy in a normal human {TK}6 lymphoblastoid cell
                      line.},
      journal      = {Radiation oncology},
      volume       = {14},
      number       = {1},
      issn         = {1748-717X},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2019-00482},
      pages        = {11},
      year         = {2019},
      abstract     = {The implementation of magnetic resonance imaging (MRI)
                      guided radiotherapy (RT) continues to increase. Very limited
                      in-vitro data on the interaction of ionizing radiation and
                      magnetic fields (MF) have been published. In these
                      experiments we focused on the radiation response in a MF of
                      the TK6 human lymphoblastoid cells which are known to be
                      highly radiosensitive due to efficient radiation-induced
                      apoptosis.Clonogenicity was determined 12-14 days after
                      irradiation with 1-4 Gy 6 MV photons with or without a 1.0
                      Tesla MF. Furthermore, alterations in cell cycle
                      distribution and rates of radiation induced apoptosis (FACS
                      analysis of cells with sub-G1 DNA content) were
                      analyzed.Clonogenic survival showed an exponential
                      dose-dependence, and the radiation sensitivity parameter
                      (α = 1.57/Gy) was in accordance with earlier reports.
                      Upon comparing the clonogenic survival between the two
                      groups, identical results within error bars were obtained.
                      The survival fractions at 2 Gy were $9\%$ (without MF) and
                      $8.5\%$ (with MF), respectively.A 1.0 Tesla MF does not
                      affect the clonogenicity of TK6 cells irradiated with
                      1-4 Gy 6MV photons. This supports the use of MRI guided
                      RT, however ongoing research on the interaction of MF and
                      radiotherapy is warranted.},
      cin          = {E055 / E040 / E050},
      ddc          = {610},
      cid          = {I:(DE-He78)E055-20160331 / I:(DE-He78)E040-20160331 /
                      I:(DE-He78)E050-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30654822},
      pmc          = {pmc:PMC6337772},
      doi          = {10.1186/s13014-019-1212-5},
      url          = {https://inrepo02.dkfz.de/record/142852},
}