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@ARTICLE{Huang:142871,
      author       = {L. Huang$^*$ and L. Jansen$^*$ and Y. Balavarca$^*$ and E.
                      Molina-Montes and M. Babaei$^*$ and L. van der Geest and V.
                      Lemmens and L. Van Eycken and H. De Schutter and T. B.
                      Johannesen and C. W. Fristrup and M. B. Mortensen and M.
                      Primic-Žakelj and V. Zadnik and N. Becker$^*$ and T.
                      Hackert and M. Mägi and T. Cassetti and R. Sassatelli and
                      R. Grützmann and S. Merkel and A. F. Gonçalves and M. J.
                      Bento and P. Hegyi and G. Lakatos and A. Szentesi and M.
                      Moreau and T. van de Velde and A. Broeks and M. Sant and P.
                      Minicozzi and V. Mazzaferro and F. X. Real and A. Carrato
                      and X. Molero and M. G. Besselink and N. Malats and M. W.
                      Büchler and P. Schrotz-King$^*$ and H. Brenner$^*$},
      title        = {{R}esection of pancreatic cancer in {E}urope and {USA}: an
                      international large-scale study highlighting large
                      variations.},
      journal      = {Gut},
      volume       = {68},
      number       = {1},
      issn         = {1468-3288},
      address      = {London},
      publisher    = {BMJ Publishing Group},
      reportid     = {DKFZ-2019-00501},
      pages        = {130 - 139},
      year         = {2019},
      abstract     = {Resection can potentially cure resectable pancreatic cancer
                      (PaC) and significantly prolong survival in some patients.
                      This large-scale international study aimed to investigate
                      variations in resection for PaC in Europe and USA and
                      determinants for its utilisation.Data from six European
                      population-based cancer registries and the US Surveillance,
                      Epidemiology, and End Results Program database during
                      2003-2016 were analysed. Age-standardised resection rates
                      for overall and stage I-II PaCs were computed. Associations
                      between resection and demographic and clinical parameters
                      were assessed using multivariable logistic regression
                      models.A total of 153 698 records were analysed. In
                      population-based registries in 2012-2014, resection rates
                      ranged from $13.2\%$ (Estonia) to $21.2\%$ (Slovenia)
                      overall and from $34.8\%$ (Norway) to $68.7\%$ (Denmark) for
                      stage I-II tumours, with great international variations.
                      During 2003-2014, resection rates only increased in USA, the
                      Netherlands and Denmark. Resection was significantly less
                      frequently performed with more advanced tumour stage (ORs
                      for stage III and IV versus stage I-II tumours: 0.05-0.18
                      and 0.01-0.06 across countries) and increasing age (ORs for
                      patients 70-79 and ≥80 versus those <60 years: 0.37-0.63
                      and 0.03-0.16 across countries). Patients with
                      advanced-stage tumours (stage III-IV: $63.8\%-81.2\%)$ and
                      at older ages (≥70 years: $52.6\%-59.5\%)$ receiving less
                      frequently resection comprised the majority of diagnosed
                      cases. Patient performance status, tumour location and size
                      were also associated with resection application.Rates of PaC
                      resection remain low in Europe and USA with great
                      international variations. Further studies are warranted to
                      explore reasons for these variations.},
      cin          = {C070 / C120 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29158237},
      doi          = {10.1136/gutjnl-2017-314828},
      url          = {https://inrepo02.dkfz.de/record/142871},
}