Journal Article

DKFZ-2019-00501

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Resection of pancreatic cancer in Europe and USA: an international large-scale study highlighting large variations.

Huang, L. (First author)DKFZ* ; Jansen, L.DKFZ* ; Balavarca, Y.DKFZ* ; Molina-Montes, E. ; Babaei, M.DKFZ* ; van der Geest, L. ; Lemmens, V. ; Van Eycken, L. ; De Schutter, H. ; Johannesen, T. B. ; Fristrup, C. W. ; Mortensen, M. B. ; Primic-Žakelj, M. ; Zadnik, V. ; Becker, N.DKFZ* ; Hackert, T. ; Mägi, M. ; Cassetti, T. ; Sassatelli, R. ; Grützmann, R. ; Merkel, S. ; Gonçalves, A. F. ; Bento, M. J. ; Hegyi, P. ; Lakatos, G. ; Szentesi, A. ; Moreau, M. ; van de Velde, T. ; Broeks, A. ; Sant, M. ; Minicozzi, P. ; Mazzaferro, V. ; Real, F. X. ; Carrato, A. ; Molero, X. ; Besselink, M. G. ; Malats, N. ; Büchler, M. W. ; Schrotz-King, P.DKFZ* ; Brenner, H. (Last author)DKFZ*

2019
BMJ Publishing Group London

This record in other databases:  

Please use a persistent id in citations: doi:10.1136/gutjnl-2017-314828

Abstract: Resection can potentially cure resectable pancreatic cancer (PaC) and significantly prolong survival in some patients. This large-scale international study aimed to investigate variations in resection for PaC in Europe and USA and determinants for its utilisation.Data from six European population-based cancer registries and the US Surveillance, Epidemiology, and End Results Program database during 2003-2016 were analysed. Age-standardised resection rates for overall and stage I-II PaCs were computed. Associations between resection and demographic and clinical parameters were assessed using multivariable logistic regression models.A total of 153 698 records were analysed. In population-based registries in 2012-2014, resection rates ranged from 13.2% (Estonia) to 21.2% (Slovenia) overall and from 34.8% (Norway) to 68.7% (Denmark) for stage I-II tumours, with great international variations. During 2003-2014, resection rates only increased in USA, the Netherlands and Denmark. Resection was significantly less frequently performed with more advanced tumour stage (ORs for stage III and IV versus stage I-II tumours: 0.05-0.18 and 0.01-0.06 across countries) and increasing age (ORs for patients 70-79 and ≥80 versus those <60 years: 0.37-0.63 and 0.03-0.16 across countries). Patients with advanced-stage tumours (stage III-IV: 63.8%-81.2%) and at older ages (≥70 years: 52.6%-59.5%) receiving less frequently resection comprised the majority of diagnosed cases. Patient performance status, tumour location and size were also associated with resection application.Rates of PaC resection remain low in Europe and USA with great international variations. Further studies are warranted to explore reasons for these variations.

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Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)
2. Präventive Onkologie (C120)
3. DKTK Heidelberg (L101)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2019

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Database coverage:
; Allianz-Lizenz ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 15 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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