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@ARTICLE{Jiang:142873,
author = {X. Jiang and H. K. Finucane and F. R. Schumacher and S. L.
Schmit and J. P. Tyrer and Y. Han and K. Michailidou and C.
Lesseur and K. B. Kuchenbaecker and J. Dennis and D. V.
Conti and G. Casey and M. M. Gaudet and J. R. Huyghe and D.
Albanes and M. C. Aldrich and A. S. Andrew and I. L.
Andrulis and H. Anton-Culver and A. C. Antoniou and N. N.
Antonenkova and S. M. Arnold and K. J. Aronson and B. K.
Arun and E. V. Bandera and R. B. Barkardottir and D. R.
Barnes and J. Batra and M. W. Beckmann and J. Benitez and S.
Benlloch and A. Berchuck and S. I. Berndt and H.
Bickeböller and S. A. Bien and C. Blomqvist and S. Boccia
and N. V. Bogdanova and S. E. Bojesen and M. K. Bolla and H.
Brauch$^*$ and H. Brenner$^*$ and J. D. Brenton and M. N.
Brook and J. Brunet and H. Brunnström and D. D. Buchanan
and B. Burwinkel$^*$ and R. Butzow and G. Cadoni and T.
Caldés and M. A. Caligo and I. Campbell and P. T. Campbell
and G. Cancel-Tassin and L. Cannon-Albright and D. Campa and
N. Caporaso and A. L. Carvalho and A. T. Chan and J.
Chang-Claude$^*$ and S. J. Chanock and C. Chen and D. C.
Christiani and K. B. M. Claes and F. Claessens and J.
Clements and J. M. Collée and M. C. Correa and F. J. Couch
and A. Cox and J. M. Cunningham and C. Cybulski and K. Czene
and M. B. Daly and A. deFazio and P. Devilee and O. Diez and
M. Gago-Dominguez and J. L. Donovan and T. Dörk and E. J.
Duell and A. M. Dunning and M. Dwek and D. M. Eccles and C.
K. Edlund and D. R. V. Edwards and C. Ellberg and D. G.
Evans and P. A. Fasching and R. L. Ferris and T. Liloglou
and J. C. Figueiredo and O. Fletcher and R.
Turzanski-Fortner$^*$ and F. Fostira and S. Franceschi and
E. Friedman and S. J. Gallinger and P. A. Ganz and J. Garber
and J. A. García-Sáenz and S. A. Gayther and G. G. Giles
and A. K. Godwin and M. S. Goldberg and D. E. Goldgar and E.
L. Goode and M. T. Goodman and G. Goodman and K. Grankvist
and M. H. Greene and H. Gronberg and J. Gronwald and P.
Guénel and N. Håkansson and P. Hall and U. Hamann$^*$ and
F. C. Hamdy and R. J. Hamilton and J. Hampe and A. Haugen
and F. Heitz and R. Herrero and P. Hillemanns and M.
Hoffmeister$^*$ and E. Høgdall and Y.-C. Hong and J. L.
Hopper and R. Houlston and P. J. Hulick and D. J. Hunter and
D. G. Huntsman and G. Idos and E. N. Imyanitov and S. A.
Ingles and C. Isaacs and A. Jakubowska and P. James and M.
A. Jenkins and M. Johansson and M. Johansson and E. M. John
and A. D. Joshi and R. Kaneva and B. Y. Karlan and L. E.
Kelemen and T. Kühl and K.-T. Khaw and E. Khusnutdinova and
A. S. Kibel and L. A. Kiemeney and J. Kim and S. K. Kjaer
and J. A. Knight and M. Kogevinas and Z. Kote-Jarai and S.
Koutros and V. N. Kristensen and J. Kupryjanczyk and M.
Lacko and S. Lam and D. Lambrechts and M. T. Landi and P.
Lazarus and N. D. Le and E. Lee and F. Lejbkowicz and H.-J.
Lenz and G. Leslie and D. Lessel and J. Lester and D. A.
Levine and L. Li and C. I. Li and A. Lindblom and N. M.
Lindor and G. Liu and F. Loupakis and J. Lubiński and L.
Maehle and C. Maier and A. Mannermaa and L. L. Marchand and
S. Margolin and T. May and L. McGuffog and A. Meindl and P.
Middha$^*$ and A. Miller and R. L. Milne and R. J. MacInnis
and F. Modugno and M. Montagna and V. Moreno and K. B.
Moysich and L. Mucci and K. Muir and A. M. Mulligan and K.
L. Nathanson and D. E. Neal and A. R. Ness and S. L.
Neuhausen and H. Nevanlinna and P. A. Newcomb and L. F.
Newcomb and F. C. Nielsen and L. Nikitina-Zake and B. G.
Nordestgaard and R. L. Nussbaum and K. Offit and E. Olah and
A. A. A. Olama and O. I. Olopade and A. F. Olshan and H.
Olsson and A. Osorio and H. Pandha and J. Y. Park and N.
Pashayan and M. T. Parsons and T. Pejovic and K. L. Penney
and W. H. M. Peters and C. M. Phelan and A. I. Phipps and D.
Plaseska-Karanfilska and M. Pring and D. Prokofyeva and P.
Radice and K. Stefansson and S. J. Ramus and L. Raskin and
G. Rennert and H. S. Rennert and E. J. van Rensburg and M.
J. Riggan and H. A. Risch and A. Risch$^*$ and M. J. Roobol
and B. S. Rosenstein and M. A. Rossing and K. De Ruyck and
E. Saloustros and D. P. Sandler and E. J. Sawyer and M. B.
Schabath and J. Schleutker and M. K. Schmidt and V. W.
Setiawan and H. Shen and E. M. Siegel and W. Sieh and C. F.
Singer and M. L. Slattery and K. D. Sorensen and M. C.
Southey and A. B. Spurdle and J. L. Stanford and V. L.
Stevens and S. Stintzing and J. Stone and K. Sundfeldt and
R. Sutphen and A. J. Swerdlow and E. H. Tajara and C. M.
Tangen and A. Tardon and J. A. Taylor and M. D. Teare and M.
R. Teixeira and M. B. Terry and K. L. Terry and S. N.
Thibodeau and M. Thomassen and L. Bjørge and M. Tischkowitz
and A. E. Toland and D. Torres and P. A. Townsend and R. C.
Travis and N. Tung and S. S. Tworoger and C. M. Ulrich and
N. Usmani and C. M. Vachon and E. Van Nieuwenhuysen and A.
Vega and M. E. Aguado-Barrera and Q. Wang and P. M. Webb and
C. R. Weinberg and S. Weinstein and M. C. Weissler and J. N.
Weitzel and C. M. L. West and E. White and A. S. Whittemore
and H.-E. Wichmann and F. Wiklund and R. Winqvist and A.
Wolk and P. Woll and M. Woods and A. H. Wu and X. Wu and D.
Yannoukakos and W. Zheng and S. Zienolddiny and A. Ziogas
and K. K. Zorn and J. M. Lane and R. Saxena and D. Thomas
and R. J. Hung and B. Diergaarde and J. McKay and U. Peters
and L. Hsu and M. García-Closas and R. A. Eeles and G.
Chenevix-Trench and P. J. Brennan and C. A. Haiman and J.
Simard and D. F. Easton and S. B. Gruber and P. D. P.
Pharoah and A. L. Price and B. Pasaniuc and C. I. Amos and
P. Kraft and S. Lindström},
title = {{S}hared heritability and functional enrichment across six
solid cancers.},
journal = {Nature Communications},
volume = {10},
number = {1},
issn = {2041-1723},
address = {[London]},
publisher = {Nature Publishing Group UK},
reportid = {DKFZ-2019-00503},
pages = {431},
year = {2019},
abstract = {Quantifying the genetic correlation between cancers can
provide important insights into the mechanisms driving
cancer etiology. Using genome-wide association study summary
statistics across six cancer types based on a total of
296,215 cases and 301,319 controls of European ancestry,
here we estimate the pair-wise genetic correlations between
breast, colorectal, head/neck, lung, ovary and prostate
cancer, and between cancers and 38 other diseases. We
observed statistically significant genetic correlations
between lung and head/neck cancer (rg = 0.57,
p = 4.6 × 10-8), breast and ovarian cancer
(rg = 0.24, p = 7 × 10-5), breast and lung
cancer (rg = 0.18, p =1.5 × 10-6) and breast and
colorectal cancer (rg = 0.15, p = 1.1 × 10-4).
We also found that multiple cancers are genetically
correlated with non-cancer traits including smoking,
psychiatric diseases and metabolic characteristics.
Functional enrichment analysis revealed a significant excess
contribution of conserved and regulatory regions to cancer
heritability. Our comprehensive analysis of cross-cancer
heritability suggests that solid tumors arising across
tissues share in part a common germline genetic basis.},
keywords = {Neoplasm Proteins (NLM Chemicals)},
cin = {C070 / C120 / C080 / C020 / B072 / B370 / L101 / L801 /
L701},
ddc = {500},
cid = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
I:(DE-He78)C080-20160331 / I:(DE-He78)C020-20160331 /
I:(DE-He78)B072-20160331 / I:(DE-He78)B370-20160331 /
I:(DE-He78)L101-20160331 / I:(DE-He78)L801-20160331 /
I:(DE-He78)L701-20160331},
pnm = {319H - Addenda (POF3-319H)},
pid = {G:(DE-HGF)POF3-319H},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:30683880},
pmc = {pmc:PMC6347624},
doi = {10.1038/s41467-018-08054-4},
url = {https://inrepo02.dkfz.de/record/142873},
}
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