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000142883 1001_ $$0P:(DE-He78)5ba5b48bd126214d9cb66291fa4ae303$$aBreckwoldt, Michael$$b0$$eFirst author
000142883 245__ $$aCorrelated MRI and Ultramicroscopy (MR-UM) of Brain Tumors Reveals Vast Heterogeneity of Tumor Infiltration and Neoangiogenesis in Preclinical Models and Human Disease.
000142883 260__ $$aLausanne$$bFrontiers Research Foundation$$c2019
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000142883 520__ $$aDiffuse tumor infiltration into the adjacent parenchyma is an effective dissemination mechanism of brain tumors. We have previously developed correlated high field magnetic resonance imaging and ultramicroscopy (MR-UM) to study neonangiogenesis in a glioma model. In the present study we used MR-UM to investigate tumor infiltration and neoangiogenesis in a translational approach. We compare infiltration and neoangiogenesis patterns in four brain tumor models and the human disease: whereas the U87MG glioma model resembles brain metastases with an encapsulated growth and extensive neoangiogenesis, S24 experimental gliomas mimic IDH1 wildtype glioblastomas, exhibiting infiltration into the adjacent parenchyma and along white matter tracts to the contralateral hemisphere. MR-UM resolves tumor infiltration and neoangiogenesis longitudinally based on the expression of fluorescent proteins, intravital dyes or endogenous contrasts. Our study demonstrates the huge morphological diversity of brain tumor models regarding their infiltrative and neoangiogenic capacities and further establishes MR-UM as a platform for translational neuroimaging.
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000142883 7001_ $$0P:(DE-HGF)0$$aBode, Julia$$b1
000142883 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b2
000142883 7001_ $$0P:(DE-He78)d9984bb7c7ce85fffd8c63899fb1d7fa$$aKrüwel, Thomas$$b3
000142883 7001_ $$0P:(DE-He78)aceff95b461bf57aaa3c92ea45b28233$$aSolecki, Gergely$$b4
000142883 7001_ $$aHahn, Artur$$b5
000142883 7001_ $$0P:(DE-He78)7f9dda5a1b9a9ffc384598e80ade05f9$$aWirthschaft, Peter$$b6
000142883 7001_ $$0P:(DE-He78)5b87d282e810365cc9599b1384318145$$aBerghoff, Anna S$$b7
000142883 7001_ $$aHaas, Maximilian$$b8
000142883 7001_ $$0P:(DE-HGF)0$$aVenkataramani, Varun$$b9
000142883 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$avon Deimling, Andreas$$b10
000142883 7001_ $$0P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aWick, Wolfgang$$b11
000142883 7001_ $$aHerold-Mende, Christel$$b12
000142883 7001_ $$aHeiland, Sabine$$b13
000142883 7001_ $$0P:(DE-He78)5ef8651b0f857b9c640aa5b1498c43b5$$aPlatten, Michael$$b14
000142883 7001_ $$aBendszus, Martin$$b15
000142883 7001_ $$aKurz, Felix T$$b16
000142883 7001_ $$0P:(DE-He78)6c294453ee36ad59deddc5494fa6aa4b$$aWinkler, Frank$$b17
000142883 7001_ $$0P:(DE-He78)a33ae52a1d80b847405db3ab83b9e90d$$aTews, Björn$$b18$$eLast author
000142883 773__ $$0PERI:(DE-600)2411902-7$$a10.3389/fnins.2018.01004$$gVol. 12, p. 1004$$p1004$$tFrontiers in neuroscience$$v12$$x1662-453X$$y2019
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