Journal Article

DKFZ-2019-00513

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Correlated MRI and Ultramicroscopy (MR-UM) of Brain Tumors Reveals Vast Heterogeneity of Tumor Infiltration and Neoangiogenesis in Preclinical Models and Human Disease.

Breckwoldt, M. (First author)DKFZ* ; Bode, J.DKFZ* ; Sahm, F.DKFZ* ; Krüwel, T.DKFZ* ; Solecki, G.DKFZ* ; Hahn, A. ; Wirthschaft, P.DKFZ* ; Berghoff, A. S.DKFZ* ; Haas, M. ; Venkataramani, V.DKFZ* ; von Deimling, A.DKFZ* ; Wick, W.DKFZ* ; Herold-Mende, C. ; Heiland, S. ; Platten, M.DKFZ* ; Bendszus, M. ; Kurz, F. T. ; Winkler, F.DKFZ* ; Tews, B. (Last author)DKFZ*

2019
Frontiers Research Foundation Lausanne

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Please use a persistent id in citations: doi:10.3389/fnins.2018.01004

Abstract: Diffuse tumor infiltration into the adjacent parenchyma is an effective dissemination mechanism of brain tumors. We have previously developed correlated high field magnetic resonance imaging and ultramicroscopy (MR-UM) to study neonangiogenesis in a glioma model. In the present study we used MR-UM to investigate tumor infiltration and neoangiogenesis in a translational approach. We compare infiltration and neoangiogenesis patterns in four brain tumor models and the human disease: whereas the U87MG glioma model resembles brain metastases with an encapsulated growth and extensive neoangiogenesis, S24 experimental gliomas mimic IDH1 wildtype glioblastomas, exhibiting infiltration into the adjacent parenchyma and along white matter tracts to the contralateral hemisphere. MR-UM resolves tumor infiltration and neoangiogenesis longitudinally based on the expression of fluorescent proteins, intravital dyes or endogenous contrasts. Our study demonstrates the huge morphological diversity of brain tumor models regarding their infiltrative and neoangiogenic capacities and further establishes MR-UM as a platform for translational neuroimaging.

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Contributing Institute(s):

1. Neuroimmunologie und Hirntumorimmunologie (D170)
2. AG Molekulare Mechanismen der Tumorzell-Invasion (V077)
3. KKE Neuropathologie (B300)
4. KKE Neuroonkologie (B320)
5. DKTK Heidelberg (L101)

Research Program(s):

1. 314 - Tumor immunology (POF3-314) (POF3-314)

Appears in the scientific report 2019

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Database coverage:
; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; DOAJ Seal ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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