TY  - JOUR
AU  - Breckwoldt, Michael
AU  - Bode, Julia
AU  - Sahm, Felix
AU  - Krüwel, Thomas
AU  - Solecki, Gergely
AU  - Hahn, Artur
AU  - Wirthschaft, Peter
AU  - Berghoff, Anna S
AU  - Haas, Maximilian
AU  - Venkataramani, Varun
AU  - von Deimling, Andreas
AU  - Wick, Wolfgang
AU  - Herold-Mende, Christel
AU  - Heiland, Sabine
AU  - Platten, Michael
AU  - Bendszus, Martin
AU  - Kurz, Felix T
AU  - Winkler, Frank
AU  - Tews, Björn
TI  - Correlated MRI and Ultramicroscopy (MR-UM) of Brain Tumors Reveals Vast Heterogeneity of Tumor Infiltration and Neoangiogenesis in Preclinical Models and Human Disease.
JO  - Frontiers in neuroscience
VL  - 12
SN  - 1662-453X
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - DKFZ-2019-00513
SP  - 1004
PY  - 2019
AB  - Diffuse tumor infiltration into the adjacent parenchyma is an effective dissemination mechanism of brain tumors. We have previously developed correlated high field magnetic resonance imaging and ultramicroscopy (MR-UM) to study neonangiogenesis in a glioma model. In the present study we used MR-UM to investigate tumor infiltration and neoangiogenesis in a translational approach. We compare infiltration and neoangiogenesis patterns in four brain tumor models and the human disease: whereas the U87MG glioma model resembles brain metastases with an encapsulated growth and extensive neoangiogenesis, S24 experimental gliomas mimic IDH1 wildtype glioblastomas, exhibiting infiltration into the adjacent parenchyma and along white matter tracts to the contralateral hemisphere. MR-UM resolves tumor infiltration and neoangiogenesis longitudinally based on the expression of fluorescent proteins, intravital dyes or endogenous contrasts. Our study demonstrates the huge morphological diversity of brain tumor models regarding their infiltrative and neoangiogenic capacities and further establishes MR-UM as a platform for translational neuroimaging.
LB  - PUB:(DE-HGF)16
C6  - pmid:30686972
C2  - pmc:PMC6335617
DO  - DOI:10.3389/fnins.2018.01004
UR  - https://inrepo02.dkfz.de/record/142883
ER  -