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@ARTICLE{Breckwoldt:142883,
      author       = {M. Breckwoldt$^*$ and J. Bode$^*$ and F. Sahm$^*$ and T.
                      Krüwel$^*$ and G. Solecki$^*$ and A. Hahn and P.
                      Wirthschaft$^*$ and A. S. Berghoff$^*$ and M. Haas and V.
                      Venkataramani$^*$ and A. von Deimling$^*$ and W. Wick$^*$
                      and C. Herold-Mende and S. Heiland and M. Platten$^*$ and M.
                      Bendszus and F. T. Kurz and F. Winkler$^*$ and B. Tews$^*$},
      title        = {{C}orrelated {MRI} and {U}ltramicroscopy ({MR}-{UM}) of
                      {B}rain {T}umors {R}eveals {V}ast {H}eterogeneity of {T}umor
                      {I}nfiltration and {N}eoangiogenesis in {P}reclinical
                      {M}odels and {H}uman {D}isease.},
      journal      = {Frontiers in neuroscience},
      volume       = {12},
      issn         = {1662-453X},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DKFZ-2019-00513},
      pages        = {1004},
      year         = {2019},
      abstract     = {Diffuse tumor infiltration into the adjacent parenchyma is
                      an effective dissemination mechanism of brain tumors. We
                      have previously developed correlated high field magnetic
                      resonance imaging and ultramicroscopy (MR-UM) to study
                      neonangiogenesis in a glioma model. In the present study we
                      used MR-UM to investigate tumor infiltration and
                      neoangiogenesis in a translational approach. We compare
                      infiltration and neoangiogenesis patterns in four brain
                      tumor models and the human disease: whereas the U87MG glioma
                      model resembles brain metastases with an encapsulated growth
                      and extensive neoangiogenesis, S24 experimental gliomas
                      mimic IDH1 wildtype glioblastomas, exhibiting infiltration
                      into the adjacent parenchyma and along white matter tracts
                      to the contralateral hemisphere. MR-UM resolves tumor
                      infiltration and neoangiogenesis longitudinally based on the
                      expression of fluorescent proteins, intravital dyes or
                      endogenous contrasts. Our study demonstrates the huge
                      morphological diversity of brain tumor models regarding
                      their infiltrative and neoangiogenic capacities and further
                      establishes MR-UM as a platform for translational
                      neuroimaging.},
      cin          = {D170 / V077 / B300 / B320 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)D170-20160331 / I:(DE-He78)V077-20160331 /
                      I:(DE-He78)B300-20160331 / I:(DE-He78)B320-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30686972},
      pmc          = {pmc:PMC6335617},
      doi          = {10.3389/fnins.2018.01004},
      url          = {https://inrepo02.dkfz.de/record/142883},
}