Journal Article

DKFZ-2019-00564

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Location-Dependent Patient Outcome and Recurrence Patterns in IDH1-Wildtype Glioblastoma.

Jungk, C. ; Warta, R. ; Mock, A. ; Friauf, S. ; Hug, B. ; Capper, D.DKFZ* ; Abdollahi, A.DKFZ* ; Debus, J.DKFZ* ; Bendszus, M. ; von Deimling, A.DKFZ* ; Unterberg, A. ; Herold-Mende, C.

2019
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/cancers11010122

Abstract: Recent studies suggest that glioblastomas (GBMs) contacting the subventricular zone (SVZ) as the main adult neurogenic niche confer a dismal prognosis but disregard the unique molecular and prognostic phenotype associated with isocitrate dehydrogenase 1 (IDH1) mutations. We therefore examined location-dependent prognostic factors, growth, and recurrence patterns in a consecutive cohort of 285 IDH1-wildtype GBMs. Based on pre-operative contrast-enhanced MRI, patients were allotted to four location-dependent groups with (SVZ+; groups I, II) and without (SVZ-; groups III, IV) SVZ involvement or with (cortex+; groups I, III) and without (cortex-; groups II, IV) cortical involvement and compared for demographic, treatment, imaging, and survival data at first diagnosis and recurrence. SVZ involvement was associated with lower Karnofsky performance score (p < 0.001), lower frequency of complete resections at first diagnosis (p < 0.0001), and lower non-surgical treatment intensity at recurrence (p < 0.001). Multivariate survival analysis employing a Cox proportional hazards model identified SVZ involvement as an independent prognosticator of inferior overall survival (p < 0.001) and survival after relapse (p = 0.041). In contrast, multifocal growth at first diagnosis (p = 0.031) and recurrence (p < 0.001), as well as distant recurrences (p < 0.0001), was more frequent in cortex+ GBMs. These findings offer the prospect for location-tailored prognostication and treatment based on factors assessable on pre-operative MRI.

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Contributing Institute(s):

1. KKE Neuropathologie (B300)
2. Translationale Radioonkologie (E210)
3. KKE Strahlentherapie (E050)
4. DKTK Heidelberg (L101)

Research Program(s):

1. 319H - Addenda (POF3-319H) (POF3-319H)

Appears in the scientific report 2019

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Database coverage:
; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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