%0 Journal Article
%A Regnery, Sebastian
%A Adeberg, Sebastian
%A Dreher, Constantin
%A Oberhollenzer, Johanna
%A Meissner, Jan-Eric
%A Goerke, Steffen
%A Windschuh, Johannes
%A Deike-Hofmann, Katerina
%A Bickelhaupt, Sebastian
%A Zaiss, Moritz
%A Radbruch, Alexander
%A Bendszus, Martin
%A Wick, Wolfgang
%A Unterberg, Andreas
%A Rieken, Stefan
%A Debus, Jürgen
%A Bachert, Peter
%A Ladd, Mark
%A Schlemmer, Heinz-Peter
%A Paech, Daniel
%T Chemical exchange saturation transfer MRI serves as predictor of early progression in glioblastoma patients.
%J OncoTarget
%V 9
%N 47
%@ 1949-2553
%C [S.l.]
%I Impact Journals LLC
%M DKFZ-2019-00743
%P 28772-28783
%D 2018
%X To prospectively investigate chemical exchange saturation transfer (CEST) MRI in glioblastoma patients as predictor of early tumor progression after first-line treatment.Twenty previously untreated glioblastoma patients underwent CEST MRI employing a 7T whole-body scanner. Nuclear Overhauser effect (NOE) as well as amide proton transfer (APT) CEST signals were isolated using Lorentzian difference (LD) analysis and relaxation compensated by the apparent exchange-dependent relaxation rate (AREX) evaluation. Additionally, NOE-weighted asymmetric magnetic transfer ratio (MTRasym) and downfield-NOE-suppressed APT (dns-APT) were calculated. Patient response to consecutive treatment was determined according to the RANO criteria. Mean signal intensities of each contrast in the whole tumor area were compared between early-progressive and stable disease.Pre-treatment tumor signal intensity differed significantly regarding responsiveness to first-line therapy in NOE-LD (p = 0.0001), NOE-weighted MTRasym (p = 0.0186) and dns-APT (p = 0.0328) contrasts. Hence, significant prediction of early progression was possible employing NOE-LD (AUC = 0.98, p = 0.0005), NOE-weighted MTRasym (AUC = 0.83, p = 0.0166) and dns-APT (AUC = 0.80, p = 0.0318). The NOE-LD provided the highest sensitivity (91
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29983895
%2 pmc:PMC6033360
%R 10.18632/oncotarget.25594
%U https://inrepo02.dkfz.de/record/143134