Journal Article

DKFZ-2019-00743

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Chemical exchange saturation transfer MRI serves as predictor of early progression in glioblastoma patients.

Regnery, S. (First author)DKFZ* ; Adeberg, S. ; Dreher, C.DKFZ* ; Oberhollenzer, J.DKFZ* ; Meissner, J.-E.DKFZ* ; Goerke, S.DKFZ* ; Windschuh, J.DKFZ* ; Deike-Hofmann, K.DKFZ* ; Bickelhaupt, S.DKFZ* ; Zaiss, M. ; Radbruch, A.DKFZ* ; Bendszus, M. ; Wick, W.DKFZ* ; Unterberg, A. ; Rieken, S. ; Debus, J. ; Bachert, P.DKFZ* ; Ladd, M.DKFZ* ; Schlemmer, H.-P.DKFZ* ; Paech, D. (Last author)DKFZ*

2018
Impact Journals LLC [S.l.]

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Please use a persistent id in citations: doi:10.18632/oncotarget.25594

Abstract: To prospectively investigate chemical exchange saturation transfer (CEST) MRI in glioblastoma patients as predictor of early tumor progression after first-line treatment.Twenty previously untreated glioblastoma patients underwent CEST MRI employing a 7T whole-body scanner. Nuclear Overhauser effect (NOE) as well as amide proton transfer (APT) CEST signals were isolated using Lorentzian difference (LD) analysis and relaxation compensated by the apparent exchange-dependent relaxation rate (AREX) evaluation. Additionally, NOE-weighted asymmetric magnetic transfer ratio (MTRasym) and downfield-NOE-suppressed APT (dns-APT) were calculated. Patient response to consecutive treatment was determined according to the RANO criteria. Mean signal intensities of each contrast in the whole tumor area were compared between early-progressive and stable disease.Pre-treatment tumor signal intensity differed significantly regarding responsiveness to first-line therapy in NOE-LD (p = 0.0001), NOE-weighted MTRasym (p = 0.0186) and dns-APT (p = 0.0328) contrasts. Hence, significant prediction of early progression was possible employing NOE-LD (AUC = 0.98, p = 0.0005), NOE-weighted MTRasym (AUC = 0.83, p = 0.0166) and dns-APT (AUC = 0.80, p = 0.0318). The NOE-LD provided the highest sensitivity (91%) and specificity (100%).CEST derived contrasts, particularly NOE-weighted imaging and dns-APT, yielded significant predictors of early progression after fist-line therapy in glioblastoma. Therefore, CEST MRI might be considered as non-invasive tool for customization of treatment in the future.

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Contributing Institute(s):

1. Radiologie (E010)
2. Medizinische Physik in der Radiologie (E020)
3. Neuroonkologische Bildgebung (E012)
4. KKE Neuroonkologie (G370)

Research Program(s):

1. 315 - Imaging and radiooncology (POF3-315) (POF3-315)

Appears in the scientific report 2018

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Database coverage:
; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS

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