%0 Journal Article
%A Watts, Eleanor L
%A Perez-Cornago, Aurora
%A Appleby, Paul N
%A Albanes, Demetrius
%A Ardanaz, Eva
%A Black, Amanda
%A Bueno-de-Mesquita, H Bas
%A Chan, June M
%A Chen, Chu
%A Chubb, S A Paul
%A Cook, Michael B
%A Deschasaux, Mélanie
%A Donovan, Jenny L
%A English, Dallas R
%A Flicker, Leon
%A Freedman, Neal D
%A Galan, Pilar
%A Giles, Graham G
%A Giovannucci, Edward L
%A Gunter, Marc J
%A Habel, Laurel A
%A Häggström, Christel
%A Haiman, Christopher
%A Hamdy, Freddie C
%A Hercberg, Serge
%A Holly, Jeff M
%A Huang, Jiaqi
%A Huang, Wen-Yi
%A Johansson, Mattias
%A Kaaks, Rudolf
%A Kubo, Tatsuhiko
%A Lane, J Athene
%A Layne, Tracy M
%A Le Marchand, Loic
%A Martin, Richard M
%A Metter, E Jeffrey
%A Mikami, Kazuya
%A Milne, Roger L
%A Morris, Howard A
%A Mucci, Lorelei A
%A Neal, David E
%A Neuhouser, Marian L
%A Oliver, Steven E
%A Overvad, Kim
%A Ozasa, Kotaro
%A Pala, Valeria
%A Pernar, Claire H
%A Pollak, Michael
%A Rowlands, Mari-Anne
%A Schaefer, Catherine A
%A Schenk, Jeannette M
%A Stattin, Pär
%A Tamakoshi, Akiko
%A Thysell, Elin
%A Touvier, Mathilde
%A Trichopoulou, Antonia
%A Tsilidis, Konstantinos K
%A Van Den Eeden, Stephen K
%A Weinstein, Stephanie J
%A Wilkens, Lynne
%A Yeap, Bu B
%A Key, Timothy J
%A Allen, Naomi E
%A Travis, Ruth C
%T The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies.
%J International journal of cancer
%V 145
%N 12
%@ 1097-0215
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2019-00977
%P 3244-3256
%D 2019
%X Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30873591
%R 10.1002/ijc.32276
%U https://inrepo02.dkfz.de/record/143389