Journal Article

DKFZ-2019-00977

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies.

Watts, E. L. ; Perez-Cornago, A. ; Appleby, P. N. ; Albanes, D. ; Ardanaz, E. ; Black, A. ; Bueno-de-Mesquita, H. B. ; Chan, J. M. ; Chen, C. ; Chubb, S. A. P. ; Cook, M. B. ; Deschasaux, M. ; Donovan, J. L. ; English, D. R. ; Flicker, L. ; Freedman, N. D. ; Galan, P. ; Giles, G. G. ; Giovannucci, E. L. ; Gunter, M. J. ; Habel, L. A. ; Häggström, C. ; Haiman, C. ; Hamdy, F. C. ; Hercberg, S. ; Holly, J. M. ; Huang, J. ; Huang, W.-Y. ; Johansson, M. ; Kaaks, R.DKFZ* ; Kubo, T. ; Lane, J. A. ; Layne, T. M. ; Le Marchand, L. ; Martin, R. M. ; Metter, E. J. ; Mikami, K. ; Milne, R. L. ; Morris, H. A. ; Mucci, L. A. ; Neal, D. E. ; Neuhouser, M. L. ; Oliver, S. E. ; Overvad, K. ; Ozasa, K. ; Pala, V. ; Pernar, C. H. ; Pollak, M. ; Rowlands, M.-A. ; Schaefer, C. A. ; Schenk, J. M. ; Stattin, P. ; Tamakoshi, A. ; Thysell, E. ; Touvier, M. ; Trichopoulou, A. ; Tsilidis, K. K. ; Van Den Eeden, S. K. ; Weinstein, S. J. ; Wilkens, L. ; Yeap, B. B. ; Key, T. J. ; Allen, N. E. ; Travis, R. C.

2019
Wiley-Liss Bognor Regis

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Please use a persistent id in citations: doi:10.1002/ijc.32276

Abstract: Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.

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Contributing Institute(s):

1. Epidemiologie von Krebserkrankungen (C020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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