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000143389 1001_ $$00000-0001-9229-2589$$aWatts, Eleanor L$$b0
000143389 245__ $$aThe associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies.
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000143389 520__ $$aInsulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.
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000143389 7001_ $$aPerez-Cornago, Aurora$$b1
000143389 7001_ $$aAppleby, Paul N$$b2
000143389 7001_ $$aAlbanes, Demetrius$$b3
000143389 7001_ $$aArdanaz, Eva$$b4
000143389 7001_ $$aBlack, Amanda$$b5
000143389 7001_ $$aBueno-de-Mesquita, H Bas$$b6
000143389 7001_ $$aChan, June M$$b7
000143389 7001_ $$aChen, Chu$$b8
000143389 7001_ $$aChubb, S A Paul$$b9
000143389 7001_ $$aCook, Michael B$$b10
000143389 7001_ $$aDeschasaux, Mélanie$$b11
000143389 7001_ $$aDonovan, Jenny L$$b12
000143389 7001_ $$aEnglish, Dallas R$$b13
000143389 7001_ $$aFlicker, Leon$$b14
000143389 7001_ $$aFreedman, Neal D$$b15
000143389 7001_ $$aGalan, Pilar$$b16
000143389 7001_ $$aGiles, Graham G$$b17
000143389 7001_ $$aGiovannucci, Edward L$$b18
000143389 7001_ $$aGunter, Marc J$$b19
000143389 7001_ $$aHabel, Laurel A$$b20
000143389 7001_ $$00000-0001-6808-4405$$aHäggström, Christel$$b21
000143389 7001_ $$aHaiman, Christopher$$b22
000143389 7001_ $$aHamdy, Freddie C$$b23
000143389 7001_ $$aHercberg, Serge$$b24
000143389 7001_ $$aHolly, Jeff M$$b25
000143389 7001_ $$00000-0002-7808-9477$$aHuang, Jiaqi$$b26
000143389 7001_ $$00000-0002-4440-3368$$aHuang, Wen-Yi$$b27
000143389 7001_ $$aJohansson, Mattias$$b28
000143389 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b29$$udkfz
000143389 7001_ $$aKubo, Tatsuhiko$$b30
000143389 7001_ $$aLane, J Athene$$b31
000143389 7001_ $$aLayne, Tracy M$$b32
000143389 7001_ $$aLe Marchand, Loic$$b33
000143389 7001_ $$aMartin, Richard M$$b34
000143389 7001_ $$aMetter, E Jeffrey$$b35
000143389 7001_ $$aMikami, Kazuya$$b36
000143389 7001_ $$aMilne, Roger L$$b37
000143389 7001_ $$aMorris, Howard A$$b38
000143389 7001_ $$aMucci, Lorelei A$$b39
000143389 7001_ $$aNeal, David E$$b40
000143389 7001_ $$aNeuhouser, Marian L$$b41
000143389 7001_ $$aOliver, Steven E$$b42
000143389 7001_ $$aOvervad, Kim$$b43
000143389 7001_ $$aOzasa, Kotaro$$b44
000143389 7001_ $$aPala, Valeria$$b45
000143389 7001_ $$aPernar, Claire H$$b46
000143389 7001_ $$aPollak, Michael$$b47
000143389 7001_ $$aRowlands, Mari-Anne$$b48
000143389 7001_ $$aSchaefer, Catherine A$$b49
000143389 7001_ $$aSchenk, Jeannette M$$b50
000143389 7001_ $$aStattin, Pär$$b51
000143389 7001_ $$aTamakoshi, Akiko$$b52
000143389 7001_ $$aThysell, Elin$$b53
000143389 7001_ $$aTouvier, Mathilde$$b54
000143389 7001_ $$aTrichopoulou, Antonia$$b55
000143389 7001_ $$00000-0002-8452-8472$$aTsilidis, Konstantinos K$$b56
000143389 7001_ $$aVan Den Eeden, Stephen K$$b57
000143389 7001_ $$aWeinstein, Stephanie J$$b58
000143389 7001_ $$aWilkens, Lynne$$b59
000143389 7001_ $$aYeap, Bu B$$b60
000143389 7001_ $$aKey, Timothy J$$b61
000143389 7001_ $$aAllen, Naomi E$$b62
000143389 7001_ $$aTravis, Ruth C$$b63
000143389 773__ $$0PERI:(DE-600)1474822-8$$a10.1002/ijc.32276$$gp. ijc.32276$$n12$$p3244-3256$$tInternational journal of cancer$$v145$$x1097-0215$$y2019
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