TY  - JOUR
AU  - Watts, Eleanor L
AU  - Perez-Cornago, Aurora
AU  - Appleby, Paul N
AU  - Albanes, Demetrius
AU  - Ardanaz, Eva
AU  - Black, Amanda
AU  - Bueno-de-Mesquita, H Bas
AU  - Chan, June M
AU  - Chen, Chu
AU  - Chubb, S A Paul
AU  - Cook, Michael B
AU  - Deschasaux, Mélanie
AU  - Donovan, Jenny L
AU  - English, Dallas R
AU  - Flicker, Leon
AU  - Freedman, Neal D
AU  - Galan, Pilar
AU  - Giles, Graham G
AU  - Giovannucci, Edward L
AU  - Gunter, Marc J
AU  - Habel, Laurel A
AU  - Häggström, Christel
AU  - Haiman, Christopher
AU  - Hamdy, Freddie C
AU  - Hercberg, Serge
AU  - Holly, Jeff M
AU  - Huang, Jiaqi
AU  - Huang, Wen-Yi
AU  - Johansson, Mattias
AU  - Kaaks, Rudolf
AU  - Kubo, Tatsuhiko
AU  - Lane, J Athene
AU  - Layne, Tracy M
AU  - Le Marchand, Loic
AU  - Martin, Richard M
AU  - Metter, E Jeffrey
AU  - Mikami, Kazuya
AU  - Milne, Roger L
AU  - Morris, Howard A
AU  - Mucci, Lorelei A
AU  - Neal, David E
AU  - Neuhouser, Marian L
AU  - Oliver, Steven E
AU  - Overvad, Kim
AU  - Ozasa, Kotaro
AU  - Pala, Valeria
AU  - Pernar, Claire H
AU  - Pollak, Michael
AU  - Rowlands, Mari-Anne
AU  - Schaefer, Catherine A
AU  - Schenk, Jeannette M
AU  - Stattin, Pär
AU  - Tamakoshi, Akiko
AU  - Thysell, Elin
AU  - Touvier, Mathilde
AU  - Trichopoulou, Antonia
AU  - Tsilidis, Konstantinos K
AU  - Van Den Eeden, Stephen K
AU  - Weinstein, Stephanie J
AU  - Wilkens, Lynne
AU  - Yeap, Bu B
AU  - Key, Timothy J
AU  - Allen, Naomi E
AU  - Travis, Ruth C
TI  - The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies.
JO  - International journal of cancer
VL  - 145
IS  - 12
SN  - 1097-0215
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2019-00977
SP  - 3244-3256
PY  - 2019
AB  - Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.
LB  - PUB:(DE-HGF)16
C6  - pmid:30873591
DO  - DOI:10.1002/ijc.32276
UR  - https://inrepo02.dkfz.de/record/143389
ER  -