TY - JOUR AU - Watts, Eleanor L AU - Perez-Cornago, Aurora AU - Appleby, Paul N AU - Albanes, Demetrius AU - Ardanaz, Eva AU - Black, Amanda AU - Bueno-de-Mesquita, H Bas AU - Chan, June M AU - Chen, Chu AU - Chubb, S A Paul AU - Cook, Michael B AU - Deschasaux, Mélanie AU - Donovan, Jenny L AU - English, Dallas R AU - Flicker, Leon AU - Freedman, Neal D AU - Galan, Pilar AU - Giles, Graham G AU - Giovannucci, Edward L AU - Gunter, Marc J AU - Habel, Laurel A AU - Häggström, Christel AU - Haiman, Christopher AU - Hamdy, Freddie C AU - Hercberg, Serge AU - Holly, Jeff M AU - Huang, Jiaqi AU - Huang, Wen-Yi AU - Johansson, Mattias AU - Kaaks, Rudolf AU - Kubo, Tatsuhiko AU - Lane, J Athene AU - Layne, Tracy M AU - Le Marchand, Loic AU - Martin, Richard M AU - Metter, E Jeffrey AU - Mikami, Kazuya AU - Milne, Roger L AU - Morris, Howard A AU - Mucci, Lorelei A AU - Neal, David E AU - Neuhouser, Marian L AU - Oliver, Steven E AU - Overvad, Kim AU - Ozasa, Kotaro AU - Pala, Valeria AU - Pernar, Claire H AU - Pollak, Michael AU - Rowlands, Mari-Anne AU - Schaefer, Catherine A AU - Schenk, Jeannette M AU - Stattin, Pär AU - Tamakoshi, Akiko AU - Thysell, Elin AU - Touvier, Mathilde AU - Trichopoulou, Antonia AU - Tsilidis, Konstantinos K AU - Van Den Eeden, Stephen K AU - Weinstein, Stephanie J AU - Wilkens, Lynne AU - Yeap, Bu B AU - Key, Timothy J AU - Allen, Naomi E AU - Travis, Ruth C TI - The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies. JO - International journal of cancer VL - 145 IS - 12 SN - 1097-0215 CY - Bognor Regis PB - Wiley-Liss M1 - DKFZ-2019-00977 SP - 3244-3256 PY - 2019 AB - Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk. LB - PUB:(DE-HGF)16 C6 - pmid:30873591 DO - DOI:10.1002/ijc.32276 UR - https://inrepo02.dkfz.de/record/143389 ER -