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@ARTICLE{Watts:143389,
      author       = {E. L. Watts and A. Perez-Cornago and P. N. Appleby and D.
                      Albanes and E. Ardanaz and A. Black and H. B.
                      Bueno-de-Mesquita and J. M. Chan and C. Chen and S. A. P.
                      Chubb and M. B. Cook and M. Deschasaux and J. L. Donovan and
                      D. R. English and L. Flicker and N. D. Freedman and P. Galan
                      and G. G. Giles and E. L. Giovannucci and M. J. Gunter and
                      L. A. Habel and C. Häggström and C. Haiman and F. C. Hamdy
                      and S. Hercberg and J. M. Holly and J. Huang and W.-Y. Huang
                      and M. Johansson and R. Kaaks$^*$ and T. Kubo and J. A. Lane
                      and T. M. Layne and L. Le Marchand and R. M. Martin and E.
                      J. Metter and K. Mikami and R. L. Milne and H. A. Morris and
                      L. A. Mucci and D. E. Neal and M. L. Neuhouser and S. E.
                      Oliver and K. Overvad and K. Ozasa and V. Pala and C. H.
                      Pernar and M. Pollak and M.-A. Rowlands and C. A. Schaefer
                      and J. M. Schenk and P. Stattin and A. Tamakoshi and E.
                      Thysell and M. Touvier and A. Trichopoulou and K. K.
                      Tsilidis and S. K. Van Den Eeden and S. J. Weinstein and L.
                      Wilkens and B. B. Yeap and T. J. Key and N. E. Allen and R.
                      C. Travis},
      title        = {{T}he associations of anthropometric, behavioural and
                      sociodemographic factors with circulating concentrations of
                      {IGF}-{I}, {IGF}-{II}, {IGFBP}-1, {IGFBP}-2 and {IGFBP}-3 in
                      a pooled analysis of 16,024 men from 22 studies.},
      journal      = {International journal of cancer},
      volume       = {145},
      number       = {12},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2019-00977},
      pages        = {3244-3256},
      year         = {2019},
      abstract     = {Insulin-like growth factors (IGFs) and insulin-like growth
                      factor binding proteins (IGFBPs) have been implicated in the
                      aetiology of several cancers. To better understand whether
                      anthropometric, behavioural and sociodemographic factors may
                      play a role in cancer risk via IGF signalling, we examined
                      the cross-sectional associations of these exposures with
                      circulating concentrations of IGFs (IGF-I and IGF-II) and
                      IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous
                      Hormones, Nutritional Biomarkers and Prostate Cancer
                      Collaborative Group dataset includes individual participant
                      data from 16,024 male controls (i.e. without prostate
                      cancer) aged 22-89 years from 22 prospective studies.
                      Geometric means of protein concentrations were estimated
                      using analysis of variance, adjusted for relevant
                      covariates. Older age was associated with higher
                      concentrations of IGFBP-1 and IGFBP-2 and lower
                      concentrations of IGF-I, IGF-II and IGFBP-3. Higher body
                      mass index was associated with lower concentrations of
                      IGFBP-1 and IGFBP-2. Taller height was associated with
                      higher concentrations of IGF-I and IGFBP-3 and lower
                      concentrations of IGFBP-1. Smokers had higher concentrations
                      of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3
                      than nonsmokers. Higher alcohol consumption was associated
                      with higher concentrations of IGF-II and lower
                      concentrations of IGF-I and IGFBP-2. African Americans had
                      lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3
                      and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than
                      non-Hispanic whites. These findings indicate that a range of
                      anthropometric, behavioural and sociodemographic factors are
                      associated with circulating concentrations of IGFs and
                      IGFBPs in men, which will lead to a greater understanding of
                      the mechanisms through which these factors influence cancer
                      risk.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30873591},
      doi          = {10.1002/ijc.32276},
      url          = {https://inrepo02.dkfz.de/record/143389},
}