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| 100 | 1 | _ | |a Watts, Eleanor L |0 0000-0001-9229-2589 |b 0 |
| 245 | _ | _ | |a The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies. |
| 260 | _ | _ | |a Bognor Regis |c 2019 |b Wiley-Liss |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk. |
| 536 | _ | _ | |a 313 - Cancer risk factors and prevention (POF3-313) |0 G:(DE-HGF)POF3-313 |c POF3-313 |f POF III |x 0 |
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| 700 | 1 | _ | |a Perez-Cornago, Aurora |b 1 |
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| 700 | 1 | _ | |a Chan, June M |b 7 |
| 700 | 1 | _ | |a Chen, Chu |b 8 |
| 700 | 1 | _ | |a Chubb, S A Paul |b 9 |
| 700 | 1 | _ | |a Cook, Michael B |b 10 |
| 700 | 1 | _ | |a Deschasaux, Mélanie |b 11 |
| 700 | 1 | _ | |a Donovan, Jenny L |b 12 |
| 700 | 1 | _ | |a English, Dallas R |b 13 |
| 700 | 1 | _ | |a Flicker, Leon |b 14 |
| 700 | 1 | _ | |a Freedman, Neal D |b 15 |
| 700 | 1 | _ | |a Galan, Pilar |b 16 |
| 700 | 1 | _ | |a Giles, Graham G |b 17 |
| 700 | 1 | _ | |a Giovannucci, Edward L |b 18 |
| 700 | 1 | _ | |a Gunter, Marc J |b 19 |
| 700 | 1 | _ | |a Habel, Laurel A |b 20 |
| 700 | 1 | _ | |a Häggström, Christel |0 0000-0001-6808-4405 |b 21 |
| 700 | 1 | _ | |a Haiman, Christopher |b 22 |
| 700 | 1 | _ | |a Hamdy, Freddie C |b 23 |
| 700 | 1 | _ | |a Hercberg, Serge |b 24 |
| 700 | 1 | _ | |a Holly, Jeff M |b 25 |
| 700 | 1 | _ | |a Huang, Jiaqi |0 0000-0002-7808-9477 |b 26 |
| 700 | 1 | _ | |a Huang, Wen-Yi |0 0000-0002-4440-3368 |b 27 |
| 700 | 1 | _ | |a Johansson, Mattias |b 28 |
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| 700 | 1 | _ | |a Metter, E Jeffrey |b 35 |
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| 700 | 1 | _ | |a Neuhouser, Marian L |b 41 |
| 700 | 1 | _ | |a Oliver, Steven E |b 42 |
| 700 | 1 | _ | |a Overvad, Kim |b 43 |
| 700 | 1 | _ | |a Ozasa, Kotaro |b 44 |
| 700 | 1 | _ | |a Pala, Valeria |b 45 |
| 700 | 1 | _ | |a Pernar, Claire H |b 46 |
| 700 | 1 | _ | |a Pollak, Michael |b 47 |
| 700 | 1 | _ | |a Rowlands, Mari-Anne |b 48 |
| 700 | 1 | _ | |a Schaefer, Catherine A |b 49 |
| 700 | 1 | _ | |a Schenk, Jeannette M |b 50 |
| 700 | 1 | _ | |a Stattin, Pär |b 51 |
| 700 | 1 | _ | |a Tamakoshi, Akiko |b 52 |
| 700 | 1 | _ | |a Thysell, Elin |b 53 |
| 700 | 1 | _ | |a Touvier, Mathilde |b 54 |
| 700 | 1 | _ | |a Trichopoulou, Antonia |b 55 |
| 700 | 1 | _ | |a Tsilidis, Konstantinos K |0 0000-0002-8452-8472 |b 56 |
| 700 | 1 | _ | |a Van Den Eeden, Stephen K |b 57 |
| 700 | 1 | _ | |a Weinstein, Stephanie J |b 58 |
| 700 | 1 | _ | |a Wilkens, Lynne |b 59 |
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| 700 | 1 | _ | |a Allen, Naomi E |b 62 |
| 700 | 1 | _ | |a Travis, Ruth C |b 63 |
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