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| Home > Publications database > The long non-coding RNA TP73-AS1 promotes tumorigenicity of medulloblastoma cells. |
| Home > Publications database > The long non-coding RNA TP73-AS1 promotes tumorigenicity of medulloblastoma cells. |
| Journal Article | DKFZ-2019-01151 |
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2019
Wiley-Liss
Bognor Regis
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Please use a persistent id in citations: doi:10.1002/ijc.32400
Abstract: Medulloblastoma is the most common malignant brain cancer in children. Since previous studies have mainly focused on alterations in the coding genome, our understanding of the contribution of long non-coding RNAs (lncRNAs) to medulloblastoma biology is just emerging. Using patient-derived data, we show that the promoter of lncRNA TP73-AS1 is hypomethylated and that the transcript is highly expressed in the SHH subgroup. Furthermore, high expression of TP73-AS1 is correlated with poor outcome in patients with TP53 wild type SHH tumors. Silencing TP73-AS1 in medulloblastoma tumor cells induced apoptosis, while inhibited proliferation and migration were inhibited in culture. In vivo, silencing TP73-AS1 in medulloblastoma tumor cells resulted in reduced tumor growth, reduced proliferation of tumor cells, increased apoptosis leading to reduced survival of tumor bearing mice. Together, our study suggest that the lncRNA TP73-AS1 is a prognostic marker and therapeutic target in medulloblastoma tumors and serves as a proof of concept that lncRNAs are important factors in the disease. This article is protected by copyright. All rights reserved.
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